Onderzoeksprojecten en publicaties

Prof.dr. B.J.M. Mulder, Prof. dr. A.F. Moorman, AMC Amsterdam: Heart failure and cardiac repair; genes for heart repair and plasticity. (projectnr. 18)

1. van Engelen K, Topf A, Keavney BD, Goodship JA, van der Velde ET, Baars MJ, Snijder S, Moorman AF, Postma AV, Mulder BJ. 22q11.2 Deletion Syndrome is under-recognised in adult patients with tetralogy of Fallot and pulmonary atresia. Heart. 2010 Apr
2. van Engelen K, Baars MJ, van Rongen LT, van der Velde ET, Mulder BJ, Smets EM. Adults with congenital heart disease: Patients' knowledge and concerns about inheritance. Am J Med Genet A. 2011 Jun 10
3. J.B.A. van de Meerakker, K. van Engelen, I.B. Mathijssen, R.H. Lekanne dit Deprez, J. Lam MD, A.A.M. Wilde, M.J.H. Baars, M.M.A.M. Mannens, B.J.M Mulder, A.F.M. Moorman, A.V. Postma A novel autosomal dominant condition consisting of congenital heart defects and low atrial rhythm maps to chromosome 9q Eur J Hum Genet. 2011 Jul 19.
4. Klaartje van Engelen, Alex V Postma, Judith van de Meerakker, Jolien W Roos-Hesselink, Apollonia ThJM Helderman-van den Enden, Hubert W Vliegen,Thahira Rahman, Marieke JH Baars, Ulrike Bauer, Thomas Pickardt, Silke R Sperling, Antoon FM Moorman, Bernard Keavney, Judith Goodship, Sabine Klaassen, Barbara JM Mulder Ebstein anomaly may be caused by mutations in the sarcomere protein gene MYH7 Neth Heart J. 2011 May.
5.  Klaartje van Engelen, Marieke JH Baars, Alex V Postma, Barbara JM Mulder Response to letter regarding: 22q11.2 Deletion Syndrome is under-recognised in adult patients with tetralogy of Fallot and pulmonary atresia. Heart. 2011 March
6. Postma AV, van Engelen K, van de Meerakker J, Rahman T, Probst S, Baars MJ, Bauer U, Pickardt T, Sperling SR, Berger F, Moorman AF, Mulder BJ, Thierfelder L, Keavney B, Goodship J, Klaassen S. Mutations in the Sarcomere Protein Gene MYH7 in Ebstein's Anomaly. Circ Cardiovasc Genet. 2011 Feb 4.
7. Cordell HJ, Topf A, Mamasoula C, Postma AV, Bentham J. Zelenika D, Heath S, Blue G, Cosgrove C, Granados Riveron J, Darlay R, Soemedi R, Wilson IJ, Ayers KL, Rahman TJ, Hall D, Mulder BJ, Zwinderman AH, van Engelen K, Brook JD, Setchfield K, Bu'Lock FA, Thornborough C, O'Sullivan J, Stuart AG, Parsons J, Bhattacharya S, Winlaw D, Mital S, Gewillig M, Breckpot J, Devriendt K, Moorman AF, Rauch A, Lathrop GM, Keavney BD, Goodship JA. Genome-wide association study identifes loci on 12q24 and 13q32 associated with tetralogy of Fallot. Hum Mol Genet. 2013 Apr. 1
8. Cordell HJ, Bentham J, Topf A, Zelenika D, Heath S, Mamasoula C, Cosgrove C, Blue G, Granados-Riveron J, Setchfield K, Thornborough C, Breckpot J. Soemedi R, Martin R, Rahman TJ, Hall D, van Engelen K, Moorman AF, Zwinderman AH, Barnett P, Koopmann TT, Adriaens ME, Varro A, George AL Jr, dos Remedios C, Bishopric NH, Bezzina CR, O'Sullivan J, Gewillig M, Bu'Lock FA, Winlaw D, Bhattacharya S, Devriendt K, Brook JD, Mulder BJ, Mital S, Postma AV, Lathrop GM, Farrall M, Goodship JA, Keavney BD. Genome-wide association study of multiple congenital heart disease phenotypes indentifes a susceptibility locus for atrial septal defect at chromosome 4p16. Nat Genet. 2013 Jul.
9. Mamasoula C, Prentice RR, Pierscionek T, Pangilinan F, Mills JL, Druschel C, Pass K, Russel MW, Hall D, Topf A, Brown DL, Zelenika D, Bentham J, Cosgrove C, Bhattacharya S, Riveron JG, Setchfield K, Brook JD, Bu'Lock FA, Thornborough C, Rahman TJ, Doza JP, Than HL, O'Sullivan J, Stuart AG, Blue G, Winlaw D, Postma AV, Mulder BJ, Zwinderman AH. van Engelen K, Moorman AF, Rauch A, Gewillig M, Breckpot J. Devriendt K, Lathrop GM, Farrall M, Goodship JA, Cordell HJ, Brody LC, Keavney BD. Association between C677T Polymorphism of Methylene Tetrahydrofolate Reductase and Congenital Heart Disease: Meta-Analysis of 7697 Cases an 13 125 Controls. Circ Cardiovasc. Genet. 2013 aug.

Prof.dr. B.J.M. Mulder, Prof.dr. A.H. Zwinderman: Losartan in Marfan syndrome (Projectnr. 25)

1. Lilian J. Meijboom, Janneke Timmermans, Aeiko H. Zwinderman, Peter M. Engelfriet and Barbara J.M. Mulder. Aortic Root Growth in Men and Women with the Marfan’s Syndrome. J Cardiol. 2005 Nov 15
2. Meijboom LJ, Vos FE, Timmermans J, Boers GH, Zwinderman AH, Mulder BJ Pregnancy and aortic root growth in the Marfan syndrome: a prospective study. Eur Heart J. 2005 May
3. Meijboom LJ, Timmermans J, van Tintelen JP, Nollen GJ, De Backer J, van den Berg MP, Boers GH, Mulder BJ Evaluation of left ventricular dimensions and function in Marfan’s syndrome without significant valvular regurgitation. Am J Cardiol. 2005 March 
4. deBackerJ , Nollen GJ, Devos D, Pals G, Coucke P, Verstraete K, van der Wall EE, Daepe A, Mulder BJ. Variability of aortic stiffness is not associated with the fibrillin 1 genotype in patients with Marfan's syndrome. Heart.2006 
5. Engelfriet PM, Mulder BJM. Is there benefit of beta-blocking agents in the treatment of patients with the Marfan syndrome? Int J Cardiol. 2007 Jan 18;114(3):300-2. Epub 2006 Jun 12.
6. Radonic T, de Witte P, Groenink M, de Bruin-Bon RA, Timmermans J, Scholte AJ, van den Berg MP, Baars MJ, van Tintelen JP, Kempers M, Zwinderman AH, Mulder BJ. Critical Appraisal of the Revised Ghent Criteria for Diagnosis of Marfan Syndrome. Int J Clin Genet. 2011 Feb 17.
7. Radonic T, de Witte P, Baars MJ, Zwinderman AH, Mulder BJ, Groenink M; COMPARE study group. Losartan therapy in adults with Marfan syndrome: study protocol of the multi-center randomized controlled COMPARE trial. Int J Journal Date.
8. Radonic T, de Witte P, Groenink M, de Waard V, Lutter R, van Eijk M, Jansen M, Timmermans J, Kempers M, Scholte AJ, Hilhorst-Hofstee Y, van den Berg MP, van Tintelen JP, Pals G, Baars MJ, Mulder BJ, Zwinderman AH. Inflammation aggravates disease severity in Marfan syndrome patients. PLoS One. 2012;7.  
9. Hartog AW, Franken R, Zwinderman AH, Groenink M, Mulder BJ. Current and future pharmacological treatment strategies with regard to aortic disease in Marfan syndrome.. Expert Opin Pharmacother. 2012 Apr;13.
10. Romy Franken, Alexander W. den Hartog, Michael Singh, Gerard Pals, Aeilko H. Zwinderman, Maarten Groenink, Barbara J.M. Mulder. Marfan Syndrome: Progress Report. Progress in Pediatric Cardiology. 2012 June. 
11. de Witte P, Aalberts JJ, Radonic T, Timmermans J, Scholte AJ, Zwinderman AH, Mulder BJ, Groenink M, van den Berg MP. Intrinsic biventricular dysfunction in Marfan syndrome. Heart. 2011 Dec.
12. Westenberg JJ, Scholte AJ, Vaskova Z, van der Geest RJ, Groenink M, Labadie G, van den Boogaard PJ, Radonic T, Hilhorst-Hofstee Y, Mulder BJ, Kroft LJ, Reiber JH, de Roos A. Age-related and regional changes of aortic stiffness in the marfan syndrome: Assessment with velocity-encoded MRI. J Magn Reson Imaging. 2011 Jul 14.
13. Radonic T, de Witte P, Baars MJ, Zwinderman AH, Mulder BJ, Groenink M. Losartan therapy in adults with Marfan syndrome: study protocol of the multi-center randomized controlled COMPARE trial. COMPARE study group. Trials. 2010 
14. Bruning O, Rodenburg W, Radonic T, Zwinderman AH, de Vries A, Breit TM, de Jong M. RNA isolation for transcriptomics of human and mouse small skin biopsies. BMC Res Notes. 2011 Oct
15. Franken R, den Hartog AW, de Waard V, Engele L, Radonic T, Lutter R, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Groenink M, Mulder BJ. Circulating transforming growth factor-ß as a prognostic biomarker in Marfan syndrome. Int J Cardiol. 2013 Oct. 3
16. den Hartog AW, Franken R, de Witte P, Radonic T, MarqueringHA, van der Steen WE, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Mulder BJ, Groenink M. Aortic disease in patients with Marfan syndrome: Aortic volume assessment for surveillance. Radiology, 15 june 2013
17. Groenink M, den Hartog AW, Franken R, Radonic T. de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Spijkerboer AM, Marquering HA, Zwinderman AH, Mulder BJ. Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial. Eur Heart J. 2013 sep 2.
18. Franken R, den Hartog AW, van de Riet L, Timmermans J, Scholte AJ, van den Berg MP, de Waard V, Zwinderman AH, Groenink M, Yip JW, Mulder BJ. Clinical features differ substantially between caucasian and asian populations of marfan syndrome. Circ J. 2013 Oct 25.
19. Franken R, den Hartog AW, Radonic T, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Mulder BJ, Groenink M. Effect of losartan treatment on aortic dilatation in adults with Marfan syndrome. Ned Tijdschr Geneeskd. 2014
20. Franken R, Hibender S, den Hartog AW, Radonic T, de Vries CJ, Zwinder-man AH, Groenink M, Mulder BJ, de Waard V. No beneficial effect of general and specific anti-inflammatory therapies on aortic dilatation in marfan mice. PLoS One. 2014 Sep 19;9(9):e107221.
21. Franken R, Radonic T, den Hartog AW, Groenink M, Pals G, van Eijk M, Lutter R, Mulder BJ, Zwinderman AH, de Waard V; COMPARE study group. The revised role of TGF-β in aortic aneurysms in Marfan syndrome.Netherlands Heart Journal October 2014
22. Franken R, den Hartog A, Radonic T, Micha D, Maugeri A, van Dijk FS, Meijers-Heijboer HE, Timmermans J, Scholte AJ, van den Berg MP, Groenink M, Mulder BJ, Zwinderman AH, de Waard V, Pals G.Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome.. Circ Cardiovasc Genet. 2015 Jan 22.
23. den Hartog AW, Franken R, Zwinderman AH, Timmermans J, Scholte AJ, van den Berg MP, de Waard V, Pals G, Mulder BJ, Groenink M. The risk for type B aortic dissection in marfan syndrome. Journal of the American College of Cardiology, 27 January 2015
24. Franken R, El Morabit A, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Marquering H, Planken NR, Zwinderman AH, Mulder BJ, Groenink M.Increased aortic tortuosity indicates a more severe aortic phenotype in adults with Marfan syndrome. International Journal of Cardiology, 15 May 2015
25.  Franken R, Groenink M, de Waard V,Feenstra HM, Scholte AJ, van den Berg MP, Pals G, Zwinderman AH,Timmermans J, Mulder BJ. Genotype impacts survival in Marfan syndrome. Eur Heart J. 2016 Jan 18.
26. Franken R, Mulder BJ. Aortic disease: Losartan versus atenolol in the Marfan aorta-how to treat? Nat Rev Cardiol. 2015 Jun 16.
27. den Hartog AW, Franken R, van den Berg MP, Zwinderman AH, Timmermans J, Scholte AJ, de Waard V, Spijkerboer AM, Pals G, Mulder BJ, Groenink M. The effect of losartan therapy on ventricular function in Marfan patients with haploinsufficient or dominant negative FBN1 mutations. Neth Heart J. 2016 Nov.24
28. Luijendijk P, Bouma BJ, Vriend JW, Vliegen HW, Groenink M, Mulder BJ Usefulness of exercise-induced hypertension as predictor of chronic hypertension in adults after operative therapy for aortic isthmic coarctation in childhood. Am J Cardiol. 2011 Aug 1;108(3):435-9. Epub 2011 May 6.
29. Luijendijk P, Boekholdt SM, Blom NA, Groenink M, Backx AP, Bouma BJ, Mulder BJ, De Winter RJ. Percutaneous treatment of native aortic coarctation in adults. Neth Heart J. 2011 Oct 19.
30. Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Veen G, Zwinderman AH, Mulder BJ.Rationale and design of a trial on the effect of high dose statins on cardiovascular risk in adults after successful coarctation repair. Contemp Clin Trials. 2012 Mar;33(2):410-6. Epub 2011 Nov 13.
31. Luijendijk P, Franken RJ, Vriend JW, Zwinderman AH, Vliegen HW, Winter MM, Groenink M, Bouma BJ, Mulder BJ. Increased risk for ascending aortic dilatation in patients with complex compared to simple aortic coarctation. Int J Cardiol. 2012 Feb 25.
32. Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Spijkerboer AM, Mulder BJ. Left ventricular fibrosis in adults after coarctation repair, does it play a role? Int J Cardiol. 2013, july 26
33. Luijendijk P, Stevens AW, de Bruin-Bon RH, Boekholdt SM, Vriend JW, Vliegen HW, Bouma BJ, Mulder BJ. Rates and determinants of progressive aortic valve dysfunction in aortic coarctation. Int J Cardiol,. 2013 sept. 10
34. Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Konings TC, Stroes ES, Zwinderman AH, Mulder BJ. Beneficial effect of high dose statins on the vascular wall in patients with repaired aortic coarctation. Int. J. Cardiol. 2014 sept.
35. Luijendijk P, Lu H, Heynneman FB, Huijgen R, de Groot EE, Vriend JW, Vliegen HW, Groenink M, Bouma BJ, Mulder BJ. Increased carotid intima-media thickness pre-dicts cardiovascular events in aortic coarctation.Int J Cardiol. 2014 Oct 

Dr. B.J.Bouma, Prof.dr. B.J.M. Mulder: Angiotensin II receptor blockers in patients with a systemic right ventricle. (Projectnr. 28)

1. Winter MM, Bernink FJ, Groenink M et al. Evaluating the systemic right ventricle by CMR: the importance of consistent and reproducible delineation of the cavity. J Cardiovasc Magn Reson 2008 
2. Winter MM, Bouma BJ, van Dijk AP et al. Relation of physical activity, cardiac function, exercise capacity, and quality of life in patients with a systemic right ventricle. Am J Cardiol 2008 November 1
3. Winter MM, van der Plas MN, Bouma BJ, Groenink M, Bresser P, Mulder BJ. Mechanisms for cardiac output augmentation in patients with a systemic right ventricle. Int. J.Cardiol 2009 February 22.
4. Winter MM, Mulder BJ, van der Velde ET. Letter by Winter et al regarding article: Children and adults with congenital heart disease lost to follow-up: who and when? Circulation. 2010 Mar 30
5. Winter MM, Reisma C, Kedde H, Bouma BJ, Vis JC, Luijendijk P, de Witte P, Zwinderman AH, Vliegen HW, Pieper PG, van Dijk AP, Mulder BJ. Sexuality in adult patients with congenital heart disease and their partners. Am J Cardiol. 2010 Oct 
6. Winter MM, Scherptong RW, Kumar S, Bouma BJ, Tulevski II, Tops LF, Roest AA, Vliegen HW, de Roos A, Groenink M, Mulder BJ. Ventricular response to stress predicts outcome in adult patients with a systemic right ventricle. Am Heart J. 2010 Nov
7. van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesslink JW, Zwinderman AH, Mulder BJ. Rationale and design of a trial on the effect of angiotensin II receptor blockers on the function of the systemic right ventricle. Am Heart J. 2010 Nov 
8. van der Bom T, Zomer AC, Zwinderman AH, Meijboom FJ, Bouma BJ, Mulder BJ. The changing epidemiology of congenital heart disease. Nat Rev Cardiol. 2011 Jan
9. van der Bom T, Luijendijk P, Bouma BJ, Koolbergen DR, de Groot JR, Mulder BB. Treatment of congenital heart disease: risk-reducing measures in young adults. Future Cardiol. 2011 March
10. Winter MM, van der Bom T, de Vries LC, Balducci A, Bouma BJ, Pieper PG, van Dijk AP, van der Plas MN, Picchio FM, Mulder BJ. Exercise training improves exercise capacity in adult patients with a systemic right ventricle: a randomized clinical trial. Eur Heart J. 2011 Oct 27
11. van der Bom T, Bouma BJ, Meijboom FJ, Zwinderman AH, Mulder BJ. The prevalence of adult congenital heart disease, results from a systematic review and evidence based calculation. Am Heart J. 2012  
12. van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-
    Hesselink JW, Zwinderman AH, Mulder BJ. The Effect of Valsartan on the Systemic Right Ventricular Function: A Double-Blind Randomized Placebo-Controlled Pilot Trial. Circulation. 2012 Dec 17. 
13. van der Bom T, Winter MM, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, Mulder BJ, Bouma BJ. J Am Coll Cardiol. Right ventricular end-diastolic volume combined with peak systolic blood pressure during exercise identifies patients at risk of complications in adults with a systemic right ventricle. 2013 Sept.
14. van der Bom T, Romeih S, Groenink M, Pieper PG, van Dijk AP, Helbing WA, Zwinderman AH, Mulder BJ, Bouma BJ. Evaluating the Systemic Right Ventricle by Cardiovasculair Magnetic Resonance: Short Axis or Axial slices? Cong. Heart Dis. 2014 April 2
15. van der Bom T, Winter MM, Knaake JL, Cervi E, de Vries LS, Balducci A, Meregalli PG, Pieper PG, van Dijk AP, Bonvicini M, Mulder BJ, Bouma BJ.Long-term benefits of exercise training in patients with a systemic right ventricle.Int J Cardiol. 2015 Jan 
16. van Dissel AC, Winter MM, van der Bom T, Vliegen HW, van Dijk APJ, Pieper PG, Sieswerda GT, Roos- Hesselink JW, Zwinderman AH, Mulder BJM, Bouma BJ. Long-term clinical outcomes of valsartan in patients with a systemic right ven-tricle: Follow-up of a multicenter randomized controlled trial.clinical outcomes of valsartan in patients with a systemic right ven-tricle: Follow-up of a multicenter randomized controlled trial. Int J Cardiol. 2018 Nov 10.

Dr. P.G.Pieper, UMCG Groningen: Pregnancy in congenital heart disease (ZAHARA2+ZAHARA3). (Projectnr. 31)

1. Balci A, Drenthen W, Mulder BJ, Roos-Hesselink JW, Voors AA, Vliegen HW, Moons P, Sollie KM, van Dijk AP, van Veldhuisen DJ, Pieper PG.Pregnancy in women with corrected tetralogy of Fallot:  occurrence and predictors of adverse events. Am Heart J. 2011 Feb;161(2):307-13. Epub 2011 Jan 15.
2. Balci A, Sollie KM, Mulder BJ, de Laat MW, Roos-Hesselink JW, van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, van Veldhuisen DJ, Pieper PG. Associations between cardiovascular parameters and uteroplacental Doppler (blood) flow patterns during pregnancy in women with congenital heart disease: Rationale and design of the Zwangerschap bij Aangeboren Hartafwijking (ZAHARA) II study. Am Heart J. 2011 Feb.
3. Drenthen W, Boersma E, Balci A, Moons P, Roos-Hesselink JW, Mulder BJ, Vliegen HW, van Dijk AP, Voors AA, Yap SC, van Veldhuisen DJ, Pieper PG, ZAHARA Investigators. Predictors of pregnancy complications in women with congenital heart disease. Eur Heart J. 2010 Sep 
4. Pieper PC, Balci A, Aarnoudse JG, Kampman MA, Sollie KM, Groen H, Mulder BJ, Oudijk MA, Roos-Hesslink JW, Cornette J, van Dijk AP, Spaanderman ME, Drenthen W, van Veldhuisen DJ. Uteroplacental Blood Flow, Cardiac Function and Pregnancy Outcome in Women with Congenital Heart Disease. On behalf of the ZAHARA II investigators. Circulation  2013 NOV 5.
5. Kampman MA, Balci A, van Veldhuisen DJ, van Dijk AP, Roos-Hesselink JW, Sollie-Szarynska KM, Ludwig-Ruitenberg M, van Melle JP, Mulder BJ, Pieper PG; on behalf of the ZAHARA II investigators.           N-terminal pro-B-type natriuretic peptide predicts cardiovasculair complications in pregnant women with congenital heart disease. Eur Heart J. 2013 dec 13.
6. Balci A, Sollie-Szarynska KM, van der Bijl AG, Ruys TP, Mulder BJ, Roos-Hesselink JW, van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, van Veldhuisen DJ, Pieper PG. On behalf of the ZAHARA II investigators .Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease. Heart, 2014 sept.
7. Kampman MA, Balci A, Groen H, van Dijk AP, Roos-Hesselink JW, van Melle JP, Sol-lie-Szarynska KM, Wajon EM, Mulder BJ, van Veldhuisen DJ, Pieper PG; ZAHARA II investi-gators. Cardiac function and cardiac events 1-year postpartum in women with congenital heart disease. Am Heart J. 2015 Feb
8. Kampman MA, Valente MA, van Melle JP, Balci A, Roos-Hesselink JW, Mulder BJ, van Dijk AP, Oudijk MA, Jongbloed MR, van Veldhuisen DJ, Pieper PG; ZAHARA II investigators.Cardiac adaption during pregnancy in women with congenital heart disease and healthy women..Heart. 2016 Aug 15
9. Kampman MA, Siegmund AS, Bilardo CM, van Veldhuisen DJ, Balci A, Oudijk MA, Groen H, Mulder BJ, Roos-Hesselink JW, Sieswerda G, de Laat MW, Sollie-Szarynska KM, Pieper PG;Uteroplacental Doppler flow and pregnancy outcome in women with tetralogy of Fallot.ZAHARA investigators..Ultrasound Obstet Gynecol. 2017 Feb

Prof. dr. B.J. Mulder, prof. dr. I.C. van Gelder, UMCG, dr. Z. Koyak: Arrhythmias in adults with CHD. (Projectnr. 32)

1. Koyak Z, de Groot JR, Mulder BJ. Interventional and surgical treatment of cardiac arrhythmias in adults with congenital heart disease. Expert Rev Cardiovasc Ther. 2010 Dec;8(12):1753-66.
2. Koyak Z, de Groot JR, Van Gelder IC, Bouma BJ, van Dessel PF, Budts W, van Erven L, van Dijk AP, Wilde AA, Pieper PG, Sieswerda GT, Mulder BJ.Implantable Cardioverter Defibrillator Therapy in Adults with Congenital Heart Disease: Who is at Risk of Shocks? Circ Arrhythm Electrophysiol. 2011 Nov 17.
3. Valente AM, Gauvreau K, Assenza GE, Babu-Narayan SV, Evans SP, Gatzoulis M, Groenink M, Inuzuka R, Kilner PJ, Koyak Z, Landzberg MJ, Mulder B, Powell AJ, Wald R, Geva T. Rationale and Design of an International Multicenter Registry of Patients With Repaired Tetralogy of Fallot to Define Risk Factors for Late Adverse Outcomes: The INDICATOR Cohort. Pediatr Cardiol. 2012 Jun 5.
4. Koyak Z, de Groot JR, Bouma BJ, Van Gelder IC, Budts W, Zwinderman AH, Mulder BJ. Symptomatic but not asymptomatic non-sustained ventricular tachycardia is associated with appropriate implantable cardioverter therapy in tetralogy of Fallot. Int J Cardiol. 2013 Aug.20
5. Koyak Z, Harris L, de Groot JR, et al. Sudden cardiac death in adult congenital heart disease. Circulation. 2012; 126: 1944-1954. 
6. Koyak Z, Achterbergh RC, de Groot JR, Berger F, Koolbergen DR, Bouma BJ, Lagrand WK, Hazekamp MG, Blom NA, Mulder BJ. Postoperative arrhythmias in adults with congenital heart disease: Incidence and risk factors. Int J Cardiol. 2013 okt 30.
7. Koyak Z, Kroon B, de Groot JR, Wagenaar LJ, van Dijk AP, Mulder BA, van Gelder IC, Post MC, Mulder BJ, Bouma BJ. Efficacy of antiarrhythmic drugs in adults with congential heart disease and supraventricular tachycardias. AM J Cardiol. 2013 Nov 1 
8.  Koyak Z, de Groot JR, Krimly A, Mackay TM, Bouma BJ, Silversides CK, Oechslin EN, Hoke U, van Erven L, Budts W, Van Gelder IC, Mulder BJ, Harris L. Cardiac resynchronization therapy in adults with congenital heart disease. Europace. 2017 Jan
9.  32.9 Koyak Z, de Groot JR, Bouma BJ, Zwinderman AH, Silversides CK, Oechslin EN, Budts W, Van Gelder IC, Mulder BJ, Harris L. Sudden cardiac death in adult congenital heart disease: can the unpredictable be foreseen? Europace. 2017 Mar 1

Prof. dr. B.J.M. Mulder, Dr. B.J.  Bouma, AMC Amsterdam: Right sided CHD. (Projectnr. 36)

1. Schuuring MJ, Vis JC, Duffels MG, Bouma BJ, Mulder BJ. Adult patients with pulmonary arterial hypertension due to congenital heart disease: a review on advanced medical treatment with bosentan. Ther Clin Risk Manag. 2010
2. Schuuring MJ, Bolmers PP, Mulder BJ, de Bruin-Bon RA, Koolbergen DR, Hazekamp MG, Lagrand WK, De Hert SG, de Beaumont EM, Bouma BJ.Right ventricular function declines after cardiac surgery in adult patients with congenital heart disease. Journal and Date.  
3. Schuuring MJ, Vis JC, Bouma BJ, van Dijk AP, van Melle JP, Pieper PG, Vliegen HW, Sieswerda GT, Mulder BJ. Rationale and design of a trial on the role of bosentan in Fontan patients: Improvement of exercise capacity? Journal and Date.
4. Schuuring MJ, Boekholdt SM, Windhausen A, Bouma BJ, Groenink M, Keijzers M, De Winter RJ, Koolbergen DR, Blom NA, Mulder BJ. Advanced therapy for ulmonary arterial hypertension due to congenital heart disease: a clinical perspective in a new therapeutic era. Neth Heart J. 2011 Nov 16.
5. Schuuring MJ, van Riel AC, Bouma BJ, Mulder BJ. Recent progress in treatment of pulmonary arterial hypertension due to congenital heart disease. Neth Heart J. 2011 Nov 12.
6. Schuuring MJ, van Riel AC, Vis JC, Duffels MG, van Straalen JP, Boekholdt SM, Tijssen JG, Mulder BJ, Bouma BJ. High-sensitivity Troponin T Is Associated with Poor Outcome in Adults with Pulmonary Arterial Hypertension due to Congenital Heart Disease. Congenit Heart Dis. 2012 Dec 14.
7. Schuuring MJ, Bouma BJ, Cordina R, Gatzoulis MA, Budts W, Mullen MP, VisJC, Celermajer D, Mulder BJ. Treatment of segmental pulmonary artery hypertension in adults with congenital heart disease. Int J Cardiol. 2013 Mar 20;164(1):106-10 Epub 2011 Jul 
8. Schuuring MJ, Vis JC, van Dijk AP, van Melle JP, Vliegen HW, Pieper PG, Sieswerda GT, de Bruin-Bon RH, Mulder BJ, Bouma BJ. Eur J Heart Fail. 2013 Jun. Impact of bosentan on exercise capacity in adults after the Fontan procedure: a randomized controlled trial.
9. Schuuring MJ, van Gulik EC, Koolbergen DR, Hazekamp MG, Lagrand WK, Backx AP, Mulder BJ, Bouma BJ.  Determinants of clinical right ventriicular failure after congenital heart surgery in adults. J Cardiothorac Vasc Anesth 2013 aug.27
10. Blok IM, van Riel AC, Schuuring MJ, Duffels MG, Vis JC, van Dijk AP, Hoendermis ES, Mulder BJ, Bouma BJ. Decrease in quality of life predicts mortality in adult patients with pulmonary arterial hypertension due to congenital heart disease. Netherlands Heart Journal, May 2015
11. Blok IM, van Riel AC, Mulder BJ, Bouma BJ.Management of patients with pulmonary arterial hypertension due to congenital heart disease: recent advances and future directions.Expert review of cardiovascular therapy, 16 October 2015
12. Blok IM, van Riel AC, Schuuring MJ, de bruin-Bon RH, van Dijk AP, Hoendermis ES, Zwinderman AH, Mulder BJ, Bouma BJ. The role of cystatin C as a biomarker for prognosis in pulmonary arterial hypertension due .Int J Cardiol. 2016 Apr
13. Blok IM, van Riel AC, van Dijk AP, Mulder BJ, Bouma BJ. From bosentan to maciten-tan for pulmonary arterial hypertension and adult congenital heart disease: Furt-her improvement? Int J Cardiol. 2017 jan 15
14. van Dissel AC, Mulder BJ, Bouma BJ The Changing Landscape of Pulmonary Arterial Hypertension in the Adult with Congenital Heart Disease..J Clin Med. 2017 March 
15. van Dissel AC, Blok IM, Zwinder-man AH, van Dijk APJ, Duijnhouwer AL, de Winter RJ, Mulder BJM, Bouma BJ. Prognostic value of multiple repeated biomarkers in pulmonary arterial hypertension associated with congenital heart disease. Eur J Heart Fail. 2018 Dec 6. 
16. van Dissel AC, Blok IM, Hooglugt JQ, de Haan FH, Jørstad HT, Mulder BJM, Bouma BJ, Winter MM. Safety and effectiveness of home-based, self-selected exercise training in symptomatic adults with congenital heart disease: A
    prospective, randomised, con-trolled trial. Int J Cardiol. 2019 Mar 1;278:59-64. doi: 10.1016/ j.ijcard.2018.12.042. Epub 2018 Dec 17. 
17. van Dissel AC, Winter MM, van der Bom T, Vliegen HW, van Dijk APJ, Pieper PG, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, Mulder BJM, Bouma BJ. Long-term clinical outcomes of valsartan in patients with a systemic right ventricle: Follow-up of a multicen-ter randomized controlled trial. Int J Cardiol. 2019 Mar 1;278:84- 87. doi: 10.1016/.ijcard.2018. 11.027. Epub 2018 Nov 10. 

Prof. dr. B.J. M. Mulder, dr. A.C. Zomer, dr. J.M. Kuijpers, drs. O.I. Woudstra AMC Amsterdam; Facing the future with adults with congenital heartdisease. (Projectnr. 38)

1. Zomer AC, Uiterwaal CS, der Velde ET, Tijssen JG, Mariman EC, Verheugt CL, Vaartjes I, Pieper PG, Meijboom FJ, Grobbee DE, Mulder BJ. Mortality in adult congenital heart disease: Are national registries reliable for cause of death? Int J Cardiol. 2010 July
2. Zomer AC, Vaartjes I, Uiterwaal CS, van der Velde ET, van den Merkhof LF, Baur LH, Ansink TJ, Cozijnsen L, Pieper PG, Meijboom FJ, Grobbee DE, Mulder BJ. Circumstances of death in adult congenital heart disease. Int J Cardiol. 2010 Oct.
3. Zomer AC, Verheugt CL, Vaartjes I, Uiterwaal CS, Langemeijer MM, Koolbergen DR, Hazekamp MG, van Melle JP, Konings TC, Bellersen L, Grobbee DE, Mulder BJ. Surgery in Adults With Congenital Heart Disease. Circulation. 2011 Oct.
4. Zomer AC, Vaartjes I, Grobbee DE, Mulder BJ. Adult congenital heart disease: New challenges. Int J Cardiol. 2012 Mar.
5. Zomer AC, Vaartjes I, Uiterwaal CS, van der Velde ET, Sieswerda GJ, Wajon EM, Plomp K, van Bergen PF, Verheugt CL, Krivka E, de Vries CJ, Lok DJ, Grobbee DE, Mulder BJ. Social burden and lifestyle in adults with congenital heart disease. Am J Cardiol. 2012 Jun; Epub 2012 Mar.
6. van der Bom T, Zomer AC, Zwinderman AH, Meijboom FJ, Bouma BJ, Mulder BJ. The changing epidemiology of congenital heart disease. Nat Rev Cardiol. 2011 Jan.
7.  A.C. Zomer, I. Vaartjes, E.T. van der Velde, H.M. de Jong, T.C. Konings, L.J. Wagenaar,W.F. Heesen, F. Eerens, L.H. Baur, D.E. Grobbee, B.J. Mulder.International Journal of Cardiology, April 2013 Heart failure admissions in adults with congenital heart disease; risk factors and prognosis.
8. Zomer AC, Ionescu-Ittu R, Vaartjes I, Pilote L, Mackie AS, Therrien J, Langemeijer MM, Grobbee DE, Mulder BJ, Marelli AJ; Sex differences in hospital Mortuality in Adults with Congenital Heart Disease: The impact of Reproductive Health. Journal of the American College of Cardiology,  july 2013
9. Kuijpers JM, Mulder BJ, Bouma BJ.Secundum atrial septal defect in adults: a practical review and recent developments. Netherlands Heart Journal, 23 April 2015
10. Kuijpers JM, van der Bom T, van Riel AC, Meijboom FJ, van Dijk AP, Pieper PG, Vliegen HW, Waskowsky WM, Oomen T, Zomer AC, Wagenaar LJ, Heesen WF, Roos-Hesselink JW, Zwinderman AH, Mulder BJ, Bouma BJ.Secundum atrial septal defect is associated with reduced survival in adult men.European Heart Journal, 16 April 2015
11. Kuijpers JM, Koolbergen DR, Groenink M, Peels KC, Reichert CL, Post MC, Bosker HA, Wajon EM, Zwinderman AH, Mulder BJ, Bouma BJ. Incidence, risk factors, and predictors of infective endocarditis in adult congenital heart disease: focus on the use of prosthetic material. Eur Heart J. 2017 Jan 8.
12. Kuijpers JM, Mulder BJ. Aorto-pathies in adult congenital heart disease and genetic aortopathy syndromes: management strategies and indications for surgery. Heart. 2017 Mar 7.
13. Kuijpers JM, Koolbergen DR, Groenink M, Boekholdt SM, Meijboom FJ, Jongbloed MRM, Hoendermis ES, Duijnhouwer AL, Mulder BJ, Bouma BJ. Aortic dissection and prophylactic surgery in congenital heart disease. Int J Cardiol. 2019 
14. Woudstra OI, Kuijpers JM, Meijboom FJ, Post MC, Jongbloed MRM, Duijnhouwer AL, van Dijk APJ, van Melle JP, Konings TC, Zwinderman AH, Mulder BJM, Bouma BJ. High burden of drug therapy in adult congenital heart disease: polypharmacy as marker of morbidity and mortality. Eur Heart J Cardiovas Pharmacother. 2019 Mar
15. Kuijpers JM, Vaartjes I, Bokma JP, Melle JP van, Sieswerda GT, Konings TC, Boo MB, Bilt I van der, Voogel B, Zwinderman AH, Mulder BJM, Bouma BJ. Risk of coronary artery disease in adults with congenital heart disease: A comparison with the general population. Int J Cardiol. 2020 April. 
16. Woudstra OI, Kuijpers JM, Jongbloed MRM, van Dijk APJ, Sieswerda GT, Vliegen HW, Egorova AD, Kiès P, Duijnhouwer AL, Robbers-Visser D, Konings TC, Zwinderman AH, Meijboom FJ, Mulder BJM, Bouma BJ.Medication in adults after atrial switch for transposition of the great arteries: clinical practice and recommendations Eur Heart J Cardiovasc Pharmacother. 2022 Jan

Prof. dr. B.J. Mulder, Dr. A.C.M.J. v Riel, AMC Amsterdam: Epidemiology and early detection of PAH in CHD. (Projectnr. 41)

1. van Riel AC, Schuuring MJ. van Hessen ID. Zwindermans AH, Cozijnsen L, Reichert CL, Hoorntje JC, Wagenaar LJ, Post MC, van Dijk AP, Hoendermis ES, Mulder BJ, Bouma BJ. Contempory prevalence of pulmonary arterial hypertension in adult congenital heart disease following the updated clinical classification. Int. J. Cardiol. 2014 june
2. van Riel AC, de Bruin-Bon RH, Gertsen EC, Blok IM, Mulder BJ, Bouma BJ. Simple stress echocardiography unmasks early pulmonary vascular disease in adult congenital heart disease. Int J Cardiol. 2015 Jun
3. van Riel AC, Blok IM, Zwinderman AH, Wajon EM, Sadee AS, Bakker-de Boo M, van Dijk AP, Hoendermis ES, Riezebos RK, Mulder BJ, Bouma BJ.Lifetime Risk of Pulmonary Hypertension for All Patients After Shunt Closure.J Am Coll Cardiol. 2015-9
4. van Riel AC, Schuuring MJ, van Hessen ID, van Dijk AP, Hoendermis ES, Yip JW, Mulder BJ, Bouma BJ.Treatment of pulmonary arterial hypertension in congenital heart disease in Singapore versus the Netherlands: age exceeds ethnicity in influencing clinical outcome. Neth Heart J. 2016 Jun
5. van Riel AC, Systrom DM, Oliveira RK, Lan-dzberg MJ, Mulder BJ, Bouma BJ, Maron BA, Shah AM, Waxman AB, Opotowsky AR. Development of a Right Ventricular Outflow Tract Gradient During Upright Exercise: A Hemodynamic Observation. J Am Coll Cardiol. 2017 Feb 7
6. van Riel AC, Opotowsky AR, Santos M, Rivero JM, Dhimitri A, Mulder BJ, Bouma BJ, Landzberg MJ, Waxman AB, Systrom DM, Shah AM.Accuracy of Echocardiography to Estimate Pulmonary Artery Pressures With Exercise: A Simultaneous Invasive-Noninvasive Comparison. Circ Cardiovasc Imaging. 2017 April
7. van Riel ACMJ, Systrom DM, Oliveira RKF, Landzberg MJ, Mulder BJM, Bouma BJ, Maron BA, Shah AM, Waxman AB, Opotowsky AR. Hemodynamic and metabolic characteristics associated with development of a right ventricular outflow tract pressure gradient during upright exercise. PLoS One. 2017 Jun

Prof. dr. V.M. Christoffels, AMC Amsterdam: Distal deletions in 22q11.2 in tetralogie of Fallot. (Projectnr. 42)

Prof. dr. V.M. Christoffels, AMC Amsterdam: Identifying mutations in WPW patients. (Projectnr. 43)

Prof. dr. C.R. Bezzina , AMC Amsterdam: Identification of New Genes in TGA and CCTGA using Whole Exome Sequencing. (Projectnr. 44)

1. Skoric-Milosavljecic D, Tjong FVY, Barc J, Backx APCM, Clur SB, van Spaendonck-Zwarts K, Oostra RJ, Lahrouchi N, Beekman L, Bokenkamp R, Barge-Schaapveld DQCM, Mulder BJM, Lodder EM, Bezzina CR, Postma AV. GATA6 mutations: Characterization of two novel patients and a comprehensive overvieuw of the GATA6 genotypic and phenotypic spectrum. AM J Med Gent A. 2019 Jul 12

Dr. Seema Mital, Toronto, Prof.dr.  B.J.M. Mulder, AMC Amsterdam: Genomic basis of Atrioventricular Septal defect. (Projectnr. 45)

1. Lisa C A D'Alessandro, Saeed Al Turki , Ashok Kumar Manickaraj Dorin Manase , Barbara J M Mulder , Lynn Bergin, Herschel C Rosenberg, Tapas Mondal , Elaine Gordon, Jane Lougheed, John Smythe, Koen Devriendt, Shoumo Bhattacharya, Hugh Watkins, Jamie Bentham, Sarah Bowdin, Matthew E Hurles, Seema Mital.Exome sequencing identifies rare variants in multiple genes in atrioventricular septal defect.Genet Med 2016 Feb

Dr. J. van Melle, UMC Groningen: Congenitale vaatringen. (Projectnr. 46)

Prof. dr. B.J. Mulder, dr. M.A. Sluman, AMC Amsterdam: Socio-economic outcomes of congenital heart disease. (Projectnr. 47)

1. Sluman MA, Zomer AC, Vaartjes I, Bouma BJ, Mulder BJ. Congenital Heart Disease may hurt men more than woman in job participation. Int J Cardiol. 2014 March 1
2. Sluman MA, de Man S, Mulder BJ, Sluiter JK. Occupational challenges of young adult patients with congenital heart disease. Neth Heart J. 2014 Feb.22
3. Sluman MA, Apers S,Bouma BJ, van Melle JP, Peels CH, Post MC,Waskowsky WM, Moons P, Mulder BJ. Uncertainties in insurances for adults with congenital heart disease. Int JCardiol. 2015 May 1
4. Sluman MA, Richard E, Bouma BJ, van Dalen JW, van Wanrooij LL, Groenink M, Caan MWA, Nederveen AJ, Mutsaerts HMM, Ma-joie CBLM, Schmand BA, Mulder BJM. Impact of Structural Cerebral Damage in Adults With Tetralogy of Fallot. Circulation. 2017 May 9 
5. Sluman MA, Apers S, Sluiter JK, Nieuwenhuijsen K, Moons P, Luyckx K, Kovacs AH, Thomet C, Budts W, Enomoto J, Yang HL, Jackson JL, Khairy P, Cook SC, Subramanyan R, Alday L, Eriksen K, Dellborg M, Berghammer M, Mattsson E, Mackie AS, Menahem S, Caruana M, Gosney K, Soufi A, Fernandes SM, White KS, Callus E, Kutty S, Bouma BJ, Mulder BJM; Approach-IS concortium, the International Society for Adult Congenital Heart Disease (ISACHD). Education as important predictor for succesful employment in adults with congenital heart disease worldwide. Congenit Heart Dis. 20198 Feb.4

Prof. dr. B.J. Mulder, dr. H. Yang, AMC Amsterdam: The spectrum of atrial tachyarrhytmia's in adult congenital heart disease. (Projectnr. 48)

1. Yang H, Nassif M, Khairy P, de Groot JR, Roos YB, de Winter RJ, Mulder BJ, Bouma BJ. Cardiac diagnostic work-up of ischaemic stroke. Eur Heart J. 2016 Nov 10
2. Yang H, Bouma BJ, Mulder BJM; Non vitamin K antagonist Oral anticoagu-lants for ThromboEmbolic prevention in adult congenital heart disease (NOTE) investigators. Is Initiating NOACs for Atrial Arrhythmias Safe in Adults with Congenital Heart Disease? Cardiovasc Drugs Ther. 2017 Aug
3. Yang H, Heidendael JF, de Groot JR, Konings TC, Veen G, van Dijk APF, Meijboom FJ, Sieswerda GT, Post MC, Winter MM, Mulder BJM, Bouma BJ.Oral anticoagulant therapy in adults withs congenital heart disease and atrial arrhyth: Implementation of guidelines. Int J Cardiol. 2018 April 15
4. Yang H, Kuijpers JM, Groot JR de, Konings TC, Dijk A van, Sieswerda GT, Post MC, Mulder BJM, Bouma BJ. Impact of atrial arrhythmias on outcome in adults with congenital hearts disease. Int J Cardiol. 2017

Prof. dr. C.R. Bezzina, dr. A.V. Postma, AMC Amsterdan: Identifying novel genes in patients with (non-syndromic) outflow tract defects. (Projectnr. 49)

1. Škorić-Milosavljević D, Lahrouchi N, Bosada FM, Dombrowsky G, Williams SG, Lesurf R, Tjong FVY, Walsh R, El Bouchikhi I, Breckpot J, Audain E, Ilgun A, Beekman L, Ratbi I, Strong A, Muenke M, Heide S, Muir AM, Hababa M, Cross L, Zhou D, Pastinen T; German Competence Network for Congenital Heart Defects, Zackai E, Atmani S, Ouldim K, Adadi N, Steindl K, Rauch A, Brook D, Wilsdon A, Kuipers I, Blom NA, Mulder BJ, Mefford HC, Keren B, Joset P, Kruszka P, Thiffault I, Sheppard SE, Roberts A, Lodder EM, Keavney BD, Clur SB, Mital S, Hitz MP, Christoffels VM, Postma AV, Bezzina CR. Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot. Genet Med. 2021 Oct;23(10):1952-1960. doi: 10.1038/s41436-021-01212-y. Epub 2021 Jun 10. Erratum in: Genet Med. 2021 Sep 14;:
2. Woudstra OI, Alban FTE, Bijvoet GP, de Bruin-Bon RHACM, Planken RN, Leiner T, Boekholdt SM, Warmerdam EG, Sieswerda GT, Mulder BJM, Bouma BJ, Meijboom FJ. Baffle complications in adults after atrial switch for transposition of the great arteries. Can J Cardiol. 2021 Oct 8:S0828-282X(21)00757-1. doi: 10.1016/j.cjca.2021.09.034. Epub ahead of print. PMID: 34634378.

Dr. M.J.B. van den Hoff, dr. A.V. Postma, AMC Amsterdam: Identifying mutation in the Follistatin-like I locus in patients with mitral valve prolaps. (Projectnr. 50)

1. Prakash S1, Mattiotti A1, Sylva M1, Mulder BJM2, Postma AV1,3, van den Hoff MJB1. Pathogenic variants in the Follistatin-like 1 gene (FSTL1) in patients with skeletal and atrioventricular valve disorders. Mol Genet Genomic Med.2019 Febr

Prof. dr. J. de Groot, drs. J. Vehmeijer, AMC Amsterdam: SCN5A mRNA splicing variants and sudden cardiac death in adults with congenital heart disease. (Projectnr. 51)

1. Vehmeijer JT, Koyak Z, Bokma JP, Budts W, Harris L, Mulder BJ, de Groot JR. Sudden cardiac death in adults with congenital heart disease: does QRS-complex fragmentation discriminate in structurally abnormal hearts?.Europace. 2017 Apr 10
2.  Vehmeijer JT, Koyak Z, Budts W, Harris L, Silversides CK, Oechslin EN, Bouma BJ, Zwinderman AH, Mulder BJM, de Groot JR. Prevention of Sudden Cardiac Death in Adults With Congenital Heart Dis-ease: Do the Guidelines Fall Short? Circ Arrhythm Electrophysiol. 2017 July 
3. Vehmeijer JT, Hulleman M, Kuijpers JM, Blom MT, Tan HL, Mulder BJM, de Groot JR, Koster RW. Resuscita-tion for out-of-hospital cardiac ar-rest in adults with congenital heart disease. Int J Cardiol. 2018 Oct 27
4. Vehmijer JT, Koyak Z, Zwinderman AH, Harris L, Peinado R, Oechslin EN, Silversides CK, Bouman BJ, Budts W, van Gelder IC, Oliver JM, Mulder BJM, de Groot JR. PREVENTION-ACHD: Prospective study on implantable cardioverter-defibrillator therapy and sudden cardiac death in adults with congenital heart disease; rationale and design. Neth Heart J. 2019 Jul 3
5.  Vehmeijer JT, Koyak Z, Vink AS, Budts W, Harris L, Silversides CK, Oechslin EN, Zwinderman AH, Mulder BJM, de Groot JR. Prolonged T(peak) -T (end) interval is a risk factor for sudden cardia death in adults with congenital heart disease. Congenit Heart dis. 2019 Oct.1 Prolonged T(peak) -T(end) interval is a risk factor for sudden cardiac death in adults with congenital heart disease.
6. Vehmeijer JT, Koyak Z, Leerink JM, Zwinderman AH, Harris L, Peinado R, Oechslin EN, Robbers-Visser D, Groenink M, Boekholdt SM, de Winter RJ, Oliver JM, Bouma BJ, Budts W, Van Gelder IC, Mulder BJM, de Groot JR. Identification of patients at risk of sudden cardiac death in congenital heart disease: The PRospEctiVE study on implaNTable cardIOverter defibrillator therapy and sudden cardiac death in Adults with Congenital Heart Disease (PREVENTION-ACHD). Heart Rhythm. 2021 May;18(5)

Dr. J.P van Melle, Prof. dr. R. Berger, UMC Groningen: Pulmonary vascular remodeling in the Fontan circulation. (Projectnr. 52)

1. Ridderbos FJ1, Wolff D1, Timmer A2, van Melle JP3, Ebels T4, Dickinson MG1, Timens W2, Berger RM5.Adverse pulmonary vascular remodeling in the Fontan circulation.10.1016/j.healun.2015.01.005

Prof. V. Christoffels, dr. A.V. Postma, AMC Amsterdam: Identifying mutations in patients with AVSD. (Projectnr. 53)

Dr. M. Voskuil, drs. T. Meijs, drs. E. Warmerdam, UMC Utrecht; coarctation of the aorta in the Netherlands. (Projectnr. 54)

1. Meijs TA, Warmerdam EG, Slieker MG, Krings GJ, Molenschot MMC, Meijboom FJ, Sieswerda GT, Doevendans PA, Bouma BJ, de Winter RJ, Mulder BJM, Voskuil M. Medium-term systemic blood pressure after stenting of aortic coarctation: a systematic review and meta-analysis. Heart 2019 Jul 17
2. Timion A. Meijs, Savine C. S. Minderhoud, Steven A. Muller, Robbert J. de Winter, Barbara J. M. Mulder, Joost P. van Melle, Elke S. Hoendermis, Arie P. J. van Dijk, Nicolaas P. A. Zuithoff, Gregor J. Krings, Pieter A. Doevendans, Maarten Witsenburg, Jolien W. Roos‐Hesselink, Annemien E. van den Bosch, Berto J. Bouma, and Michiel Voskuil Cardiovascular Morbidity and Mortality in Adult Patients With Repaired Aortic Coarctation JAHA, nov 2021

Dr. M. Voskuil, drs. E. Warmerdam, UMC Utrecht: Percutaneous pulmonary valve implantation in the Netherlands. (Projectnr. 55)

1. Driesen BW,  Warmerdam EG, SieswerdamGJ,  Meijboom FJ, Molenschot MC, Doevendans PA, Krings GJ, van Dijk APJ, Voskuil M. Percutaneous Pulmonary Valve Implantation: Current Status and Future Perspectives. Curr Cardiol Rev
   2019

Prof. dr. N. Blom, dr. R.L.F. van der Palen, LUMC: Transposition of the great arteries after atrial and arteriel switch procedure in the Netherlands: from newborn to elderly. (Projectnr. 56)

1. van der Palen RLF, van der Bom T, Dekker A, Tsonaka R, van Geloven N, Kuipers IM, Konings TC, Rammeloo LAJ, Ten Harkel ADJ, Jongbloed MRM, Koolbergen DR, Mulder BJM, Hazekamp MG, Blom NA. Progression of aortic root dilatation and aortic valve regurgitation after the arterial switch operation. Heart. 2019 Jul 10
2. van der Palen RLF, van der Zee C, Vink As, Knobbe I, Jurgens Sj, van Leeuwen E, Bax CJ, du Marchie Sarvaas GH, Blom NA, Haak MC, Bilardo CM, Clur SB. Transposition of the great arteries: fetal pulmonary valve growth and post-operative neo-aortic root dilatation. Prenat Diagn. 2019 Jul 27
3. van der Palen RLF, Blom NA, Kuipers IM, Rammeloo LAJ, Jongbloed MRM, Koning TC, Bouma BJ, Koolbergen DR, Hazekamp MG. Long-term outcome after the arterial switch operation: 43 years of experience. Eur J Cardiothorac Surg. 2021 May 8;59(5):

Prof. dr. B.J. Mulder, S. Nijbroek, A.C. van Dissel, AMC: PH in ACHD: pulmonary arterial hypertension versus pulmonary venous hypertension. (Projectnr. 57)

Prof. dr. B.J. Mulder, dr. M.J. Schuuring, drs. D. Kauw, AMC ; HartWacht bij volwassenen met een aangeboren hartafwijking. (Projectnr. 58)

1. Kauw D, Koole MAC, van Dorth JR, Tulevski II, Somsen GA, Schijven MP, Dohmen DAJ, Bouma BJ, Mulder BJM, Schuuring MJ, WInter MM. eHealth in patients with congenital heartdisease: a review. Expert Rev Cardiovasc. Ther. 2018sept  
2. Koole MAC, Kauw D, Winter MM, Dohmen DAJ, Tulevski II, de Haan R, Somsen GA, Schijven MP, Rob-bers-Visser D, Mulder BJM, Bouma BJ, Schuuring MJ. First real-world experience with mobile health tele-monitoring in adult patients with congenital heart disease.congenital heart disease. Neth Heart J. 2018 Nov 28.
3. Koolen MAC, Somsen GA, Tulevski II, Winter MM, Bouma BJ, Schuuring MJ. At last, mobile health leading to a diagnosis in a young patient with congenital heartdisease. Neth. Heart J. 2019 Jan.8
4. Treskes RW, Koole M, Kauw D, Winter MM, Monteiro M, Dohmen D, Abu-Hanna A, Schijven MP, Mulder BJ, Bouma BJ, Schuuring MJ. Adults with congenital heart disease: ready for mobile health? Neth. Heart J. 2019 Feb.13

Prof. dr. B.J. Mulder, drs. M. van Andel, AMC; Resveratrol as potential aortic growth inhibitor in patients with Marfan Syndrome. (Projectnr. 59)

1. van Andel MM, Groenink M, Zwin-derman AH, Mulder BJM, de Waard V. The Potential Beneficial Effects of Resveratrol on Cardio-vascular Complications in Marfan Syndrome Patients⁻Insights from Rodent-Based Animal Studies. Int J Mol Sci. 2019 Mar 5;20(5). pii: E1122. doi: 10.3390/ijms2005 1122. Review.

Prof. dr. P.H. Schoof, drs.R. Ijsselhof, UMCU; Valve replacement for LAVV dysfunction after AVSD repair. (Projectnr. 60)

1. Rinske J IJsselhof , Saniyé D R Duchateau , Rianne M Schouten , Martijn G Slieker, Mark G Hazekamp ,Paul H Schoof. Long-Term Follow-Up of Pericardium for the Ventricular Component in Atrioventricular Septal Defect Repair.World J Pediatr Congenit Heart Surg 2020 Nov

Dr. M.M. van Haelst, drs. E. Verberne, AMC: Identifying GMDS deletion in patients with Ebstein anomaly. (Projectnr. 61)

Prof. dr. C. Bezzina, dr. A. Postma, drs. D. Milosavljevic, AmsterdamUMC AMC: Rare variant association analysis in patients with transposition of the great arteries. (Projectnr. 62)

1. Škorić-Milosavljević D, Tadros R, Bosada FM, Tessadori F, van Weerd JH, Woudstra OI, Tjong FVY, Lahrouchi N, Bajolle F, Cordell HJ, Agopian AJ, Blue GM, Barge-Schaapveld DQCM, Gewillig M, Preuss C, Lodder EM, Barnett P, Ilgun A, Beekman L, van Duijvenboden K, Bokenkamp R, Müller-Nurasyid M; KORA-Study Group, Vliegen HW, Konings TC, van Melle JP, van Dijk APJ, van Kimmenade RRJ, Roos- Hesselink JW, Sieswerda GT, Meijboom F, Abdul-Khaliq H, Berger F, Dittrich S, Hitz MP, Moosmann J, Riede FT, Schubert S, Galan P, Lathrop M, Munter HM, Al- Chalabi A, Shaw CE, Shaw PJ, Morrison KE, Veldink JH, van den Berg LH, Evans S, Nobrega MA, Aneas I, Radivojkov-Blagojević M, Meitinger T, Oechslin E, Mondal T, Bergin L, Smythe JF, Altamirano-Diaz L, Lougheed J, Bouma BJ, Chaix MA, Kline J, Bassett AS, Andelfinger G, van der Palen RLF, Bouvagnet P, Clur SB, Breckpot J, Kerstjens-Frederikse WS, Winlaw DS, Bauer UMM, Mital S, Goldmuntz E, Keavney B, Bonnet D, Mulder BJ, Tanck MWT, Bakkers J, Christoffels VM, Boogerd CJ, Postma AV, Bezzina CR.Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries Circ Res. 2022 Jan 21

Prof. dr. R. de Winter, dr. B.J. Bouma, drs. L. Witte, Amsterdam UMC AMC: The global COVID-19 pandemic; are all ACHD patientes at high risk?(Projectnr. 63)

Prof. dr. R. de Winter, dr. B.J. Bouma, drs. L. Engele, Amsterdam UMC AMC: Comprehensive long term follow-up of adults with prior arterial switch operation (Projectnr. 64)

Prof. dr. J.W. Roos-Hesselink, drs. F. Meccanici, Erasmus MC Rotterdam:Congenital aortic stenosis in adults: a multicentre study (CASIA)(Projectnr. 65)

Dr. J.P. van Melle, Prof. dr. A.A. Voors, Drs. M.M. Ansari Ramandi. UMC Groningen: Systemic Right Ventricle Long-term Outcome (SINCERE): a multicentre study (Projectnr.66)

Prof. dr. N. Blom, Dr. B.J. Bouma, dr. R. vd Palen, drs. L. Engele, CAHAL/ LUMC/ AmsterdamUMC, locatie AMC: Transposition of the great arteries after the arterial switch operation in the Netherlands: from newborn to elderly (Projectnr. 67)

Dr. E.M. Lodder, Assistant Professor, Clinical Genetics (AMC), drs. K. AndrzejczykHCN4 variants association analysis in patients with pulmonary stenosis (Projectnr. 68)

Prof. dr. R.A. de Boer. dr. W.C. Meijers, UMC Groningen: Lifetime risk and potential genetic determinants of cancer in adults with congenital heart disease (Projectnr. 69)

Dr. H.L. Tan, AMC Amsterdam: Genetic basis of cardiac malformations. (Projectnr. 2)

Prof. dr.  JW Roos – Hesselink, Erasmus MC Rotterdam: Molecular etiology LVOT obstruction. (Projectnr. 3)

Prof. dr.  JW Roos - Hesselink, ErasmusMC, Rotterdam: Follow-up patients with an AICD. (Projectnr. 4)

1. Sing-Chien Yap, Jolien W. Roos-Hesselink, Elke S. Hoenermis, Werner Budts, Hubert W.Vliegen, Barbara J.M. Mulder, Arie P. van Dijk, Martin Schalij, W. Drenthen. Outcome of implantable cardioverter defibrillators in adults with congenital heart disease: a multi-centre study. Eur Heart J. 2007 Aug.
   

Drs. M. Kriek, LUMC Leiden:  Identification of genes involved in congenital heart malformations. (Projectnr. 5)

Dr. R.H. Lekanne Deprez, AMC Amsterdam: Genetic basis of congenital cardiac malformations. (Projectnr. 6)

Prof. dr. K. Devriendt, KU Leuven, Belgium: PA26, candidategen heterotaxia. (Projectnr. 7)

Dr. A.V. Postma, AMC Amsterdam: GATA4 polymorphisms in congenital heart disease. (Projectnr. 9)

Dr. J. Bakkers, Hubrecht Laboratorium Utrecht: From zebrafish to man: Mutation discovery in genes required for normal cardiac development. (Projectnr. 10)

Prof. dr. J.W. Roos-Hesselink, Erasmus MC, Rotterdam: Prospective randomised multicentre study: statines and aortic stenosis. (Projectnr. 11)

Prof. dr. R.Berger , UMCG, Groningen: TGF-ß receptor mutations in ASD. (Projectnr. 12)

{ Prof. dr. B.J.M. Mulder, AMC, Amsterdam: Pulmonary arterial hypertension. (Projectnr. 13)}

1. Duffels MGJ, Engelfriet PM, Berger RMF, van Loon RLE, Hoendermis E, Vriend JWJ, van der Velde ET, Bresser P, Mulder BJM. Pulmonary arterial hypertension in congenital heart disease: An epidemiologic perspective from a Dutch registry. Int J Cardiol 2007 Aug.
2. M.G.J. Duffels, R.M.F. Berger, P. Bresser, H.A.C.M. de Bruin-Bon, E. Hoendermis, B.J. Bouma, B.J.M. Mulder. Applicability of bosentan in Dutch patients with Eisenmenger syndrome: preliminary results on safety and exercise capacity. Neth Heart J. 2006 May
3. van Loon RL, Hoendermis ES, Duffels MG, Vonk-Noordegraaf A, Mulder BJ, Hillege HL, Berger RM. Long-term effect of bosentan in adults versus children with pulmonary arterial hypertension associated with systemic-to-pulmonary shunt: does the beneficial effect persist? Am Heart J. 2007 Oct. 
4. Duffels MG, Vis JC, van Loon RL et al. Down patients with Eisenmenger syndrome: Is bosentan treatment an option? Int J Cardiol 2008 June
5. Hamaker ME, Duffels MG, Reichert CL, Cornel JH, Mulder BJ, Umans VA. [Two patients with Eisenmenger syndrome treated with novel agents that target vasodilation of the pulmonary capillary bed]. Ned Tijdschr Geneeskd 2007 August.
6. van der Plas MN, Duffels MG, Ponse D, Mulder BJ, Bresser P. Bosentan in mild pulmonary hypertension. Lancet 2008 November 15;372(9652):1730 
7. Duffels MG, Vis JC, van Loon RL et al. Effect of bosentan on exercise capacity and quality of life in adults with pulmonary arterial hypertension associated with congenital heart disease with and without Down’s syndrome. Am J Cardiol 2009 May  
8. Duffels MG, Mulder KM, Trip MD, de Groot E, Gort J, van Dijk AP, Hoendermis ES, Daliento L, Zwinderman AH, Berger RM, Mulder BJ. Atherosclerosis in patients with cyanotic congenital heart disease. Circ J. 2010
9. Mulder BJ.Changing demographics of pulmonary arterial hypertension in congenital heart disease. Eur Respir Rev. 2010 Dec 1;19(118):308-13. 
10. Duffels M, van Loon L, Berger R, Boonstra A, Vonk-Noordegraaf A, Mulder B.Pulmonary arterial hypertension associated with a congenital heart defect: advanced medium-term medical treatment stabilizes clinical condition. Congenit Heart Dis. 2007 July

Dr. A. Hoffmann, Universiteit Basel, A multicenter retrospective analysis on cerebrovascular accidents in a population of adults with congenital heart disease. (Projectnr. 14)

1. Hoffmann A, Chockalingam P, Balint OH, Dadashev A, Dimopoulos K, Engel R, Schmid M, Schwerzmann M, Gatzoulis MA, Mulder B, Oechslin E.Cerebrovascular accidents in adult patients with congenital heart disease. Heart. 2010 Aug.

Dr. A.Van Dijk , UMCN, Nijmegen: Morbus Ebstein. (Projectnr. 15)

{sliderProf. dr. Grobbee, Dr. C.Uiterwaal, Julius Centrum, Utrecht: Prognosis in congenital heart disease. (Projectnr. 16)}

1. Verheugt CL, Uiterwaal CS, van der Velde ET, et al. Gender and outcome in adult congenital heart disease. Circulation 2008 July
2. Verheugt CL, Uiterwaal CS, Grobbee DE, Mulder BJ. Long-term prognosis of congenital heart defects: A systematic review. Int J Cardiol 2008 August.
3. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Veen G, Stappers JL, Grobbee DE, Mulder BJ. Turning 18 with congenital heart disease: prediction of infective endocarditis based on a large population. Eur Heart J. 2011 Jan.
4. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Sieswerda GT, Plokker HW, Grobbee DE, Mulder BJ. The emerging burden of hospital admissions of adults with congenital heart disease. Heart. 2010 Jun
5. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, van Dijk AP, Vliegen HW, Grobbee DE, Mulder BJ. Mortality in adult congenital heart disease. Eur Heart J. 2010 May 

Prof. dr. B.J.M. Mulder, AMC,Amsterdam: CVA bij ASD. (Projectnr. 17)

1. Lok SI, Winkens B, Dimpoulos K et al. Recurrence of cerebrovascular events in Young adults with a secundum arterial septal defect, Int J Cardiol 2009 January 24.  

Dr A. V. Postma: Replication cohort for SNP studies in Tetralogy of Fallot. (Projectnr. 19)

Dr A. van Dijk, UMCN, Nijmegen: Exercise in Congenital heart disease. (Projectnr. 20)

Dr. Postma AMC,Amsterdam, Denmark: Genes in Aortic Stenosis. (Projectnr. 21)

Prof . dr. AAM Wilde, AMC, Amsterdam: Sodium channels in septal defects. (Projectnr. 22)

Prof . dr. BJM Mulder, AMC, Amsterdam: Congenital heart defects inDown syndrome. (Projectnr. 23)

1. Vis JC, de Bruin-Bon RH, Bouma BJ, Huisman SA, Imschoot L, van den Brink K, Mulder BJ. Congenital heart defects are under-recognised in adult patients with Down's syndrome. Hearts. 2010 Sep.
2. Vis JC, Thoonsen H, Duffels MG, de Bruin-Bon RA, Huisman SA, van Dijk AP, Hoendermis ES,Berger RM, Bouma BJ, Mulder BJ. Six-minute walk test in patients with Down syndrome: validity and reproducibility.Arch Phys Med Rehabil. 2009  

Seshadri Balaji, Maully Shah, dr. Roos-Hesselink Philadelphia/Rotterdam, Arrhythmia after the Fontan operation:Comparison of the intracardial lateral Tunnel, and the extracardiac conduits procedures. (Projectnr. 24)

Prof . dr. Gittenberger, LUMC, Leiden, FP7: Genes in heart valve development. (Projectnr. 27)

Prof . dr. Willekens, Dr L. /Bonneux, NIDI / KNAW, Den Haag: Demography in CHD. (Projectnr. 29)

Prof . dr. Bhattacharya, J.Goodship, Oxford, UK: Genetic architecture of Congenital heart disease. (Projectnr. 30)

Drs. A.W. Schadenberg UMC Utrecht Neonatal thymectomy during heart surgery: consequences for the immune system in patients with TGA. (Projectnr. 33)

Dr. Joziasse, UMC Utrecht. Genemutations in patients with TGA. (Projectnr. 34)

1. Joziasse IC, van de Smagt JJ, Smith K et al. Genes in congenital heart disease: atrioventricular valve formation. Basic Res Cardiol 2008 May
2. Joziasse IC, van der Smagt, JJ Poot M et al. A duplication including GATA4 does not co-segregate with congenital heart defects. Am J Med Genet 2009 May.
3. Smith KA, Joziasse IC, Chocron S et al. Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 2009 June
4. Joziasse IC, Smith KA, Chocron S, van Dinther M, Guryev V, van de Smagt JJ, Cuppen E, Ten Dijke P, Mulder BJ, Maslen CL, Reshey B, Doevendans PA, Bakkers J.ALK2 mutation in a patient with Down's syndrome and a congenital heart defect. Eur J Hum Genet. 2011 Apr;19(4):389-93. Epub 2011 Jan.

Prof. dr. B.J.M. Mulder, Dr. K.v.Engelen, Dr. A.V. Postma; AMC Amsterdam: GATA5 a new congenital heart defect gene. (Projectnr. 35)

Prof.dr. B.J. Mulder, D. Schoormans, AMC Amsterdam: Predicting health care use and perceived health care needs in patients with congenital disease. (Projectnr. 37)

1. Schoormans D, Sprangers MA, Pieper PG, van Melle JP, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ. The Perspective of Patients with Congenital Heart Disease: Does Health Care Meet Their Needs? Congenit Heart Dis. 2011 May;6  Epub 2011 May 5.
2. Schoormans D, Mager YL, Oort FJ, Sprangers MA, Mulder BJ. New York Heart Association class assessment by cardiologists and outpatients with congenital cardiac disease: a head-to-head comparison of three patient-based versions. Cardiol Young. 2012 Feb;22(1):26-33. Epub 2011 Jul 4.
3. Schoormans D, Mulder BJ, Sprangers MA. Letter by Schoormans et al. regarding article: Recommendations for improving the quality of interdisciplinary care of grown-up with congenital heart disease (GUCH). 
4. Schoormans D, Radonic T, de Witte P, Groenink M, Azim D, Lutter R, Mulder BJ, Sprangers MA, Zwinderman AH. Mental quality of life is related to a cytokine genetic pathway. PLoS One. 2012;7(9):e45126. Epub 2012
5. Schoormans D, Smets EM, Zwart R, Sprangers MA, Veelenturg TH, de Mol BA, Hazekamp MG, Koolbergen DR, Sojak V, Bouma BJ, Groenink M, Boekholdt MS, Backx AP, Mulder BJ. Peri-operative care in adults with congenital heart disease: room for improvement in after care. Oct 2, 2012
6. Schoormans D, Sprangers MA, Budts W, Mulder BJ, Apers S, Moons P. Erratum to: Perceived health is partially associated with the symptomatological profile in patients with benign and severe conditions: the case of congenital heart disease. Oct 23, 2012
7. Schoormans D, Mulder BJ, van Melle JP, Pieper EG, van Dijk AP, Sieswerda GJ, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Sprangers MA. Patients with a congenital heart defect and type D personality feel functionally more impaired, report a poorer health and quality of life, but use less healthcare
8. Schoormans D, Mulder BJ, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Sprangers MA. Illness perceptions of adults with congenital heart disease and their predictive value for quality of life two years later. Eur J Cardiovasc Nurs. 2013 Mar 22. PMID: 23524630.
9. Schoormans D, Sprangers MA, Mulder BJ. Future challenges in providing appropriate care for adults with congenital heart disease. Int J Cardiol. 2013 Oct.3
10. Schoormans D, Sprangers MA, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ. Clinical and psychological characteristics pre-dict future healthcare use in adults with con-genital heart disease.Eur J Cardiovasc Nurs. 2014 Oct 20.
11. Schoormans D, Wierenga EA. Are adults with congenital heart disease at risk for the development of heart failure when feeling depressed? An immunological mechanism. Pediatr Cardiol. 2012 Oct; Epub 2012 May 26.
12. Kauw D, Schoormans D, Sieswerda GT, Van Melle JP, Vliegen HW, Van Dijk APJ, Hulsbergen-Zwarts MS, Post MC, Ansink TJ, Mulder BJM, Bouma BJ, Schuuring MJ. Type D Personality Associated With Increased Risk for Mortality in Adults With Congenital Heart Disease. J Cardiovasc Nurs. 2022 Mar-Apr 

Prof. dr. P. Doevendans UMC Utrecht: Genomics of the arterial pole. (Projectnr. 39)

1. Joziasse IC, Vink A, Cramer MJ, van Oosterhout MF, van Herwerden LA, Heijmen R, Sieswerda GT, Mulder BJ, Doevendans PA. Bicuspid stenotic aortic valves: clinical characteristics and morphological assessment using MRI and echocardiography. Neth Heart J. 2011 Mar;19(3):119-125. Epub 2011 Feb.  

Dr. P.G. Pieper UMC Groningen: Functional outcome and quality of life in adult congenital heart disease patients with prosthetic valves. (Projectnr. 40)

1. Freling HG, van Slooten YJ, van Melle JP, Mulder BJ, van Dijk AP, Hillege HL, Post MC, Sieswerda GT, Jongbloed MR, Willems TP, Pieper PG; On behalf of the PROSTAVA investigators. Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study.Neth Heart J. 2012 Oct;20(10) 
2.  van Slooten YJ, Freling HG, van Melle JP, Mulder BJ, Jongbloed MR, Ebels T, Voors AA, Pieper PG; Long-term tricuspid valve prothesis-related complications in patients with congenital heart disease. Eur J Cardiothorac Surg. 2013 May 17.