Onderzoeksprojecten en publicaties

8. Prof. dr. B.J.M. Mulder, AMC Amsterdam: Late complications in Tetralogy of Fallot.

8.1. Oosterhof T, Mulder BJ, Vliegen HW, de Roos A.Corrected tetralogy of Fallot: delayed enhancement in right ventricular outflow tract. Radiology. 2005 Dec;237(3):868-71.

8.2. Oosterhof, T, Meijboom, FJ, Vliegen, HW, Hazekamp, MG, Zwinderman, AH, Bouma, BJ, van Dijk, AP Mulder, BJ:Long-term follow-up of homograft function after pulmonary valve replacement in patients with tetralogy of Fallot.Eur Heart J. 2006 Jun;27(12)

8.3. Oosterhof T, Vliegen HW, Meijboom FJ, Zwinderman AH, Bouma B, Mulder BJ.Long-term effect of pulmonary valve replacement on QRS duration in patients with corrected tetralogy of Fallot. Heart. 2007 Apr;93(4):506-9.

8.4. Oosterhof T, van Straten A, Vliegen HW, Meijboom FJ, van Dijk AP, Spijkerboer AM, Bouma BJ, Zwinderman AH, Hazekamp MG, de Roos A, Mulder BJ.Preoperative thresholds for pulmonary valve replacement in patients with corrected tetralogy of Fallot using cardiovascular magnetic resonance.Circulation. 2007 Jul 31

8.5. Oosterhof T, Jacobs M, Cramer MJ, Mulder BJ.Survival into seventh decade after a potts palliation for tetralogy of Fallot. Congenit Heart Dis 2007 January;2(1)

8.6. Luijnenburg SE, Helbing WA, Moelker A, Kroft LJ, Groenink M, Roos-Hesselink JW, de Rijke YB, Hazekamp MG, Bogers AJ, Vliegen HW, Mulder BJ. 5-Year serial follow-up of clinical condition and ventricular function in patients after repai of tetralogy of Fallot. Int. J. Cardiol. 2013 nov 30.

8.7 Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG, Koolbergen DR, Groenink M, Mulder BJ, Bouma BJ. Severe tricuspid regurgitation is predictive for adverse events in tetralogy of Fallot. Heart.2015 May 15

8.8 Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG, Koolbergen DR, Groenink M, Mulder BJ, Bouma BJ.Individualised prediction of pulmonary homograft durability in tetralogy of Fallot.Heart. 14 July 2015

8.9 Bokma JP, Winter MM, Mulder BJ, Bouma BJ. Tricuspid Regurgitation Secondary to Severe Pulmonary Regurgitation: When to Operate on Which Valves?The Annals of thoracic surgery, December 2015

8.10 Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG, Koolbergen DR, Groenink M, Mulder BJ, Bouma BJ. Preoperative thresholds for mid-to-late haemodynamic and clinical outcomes after pulmonary valve replacement in tetralogy of Fallot.European Heart Journal, 2016 March

8.11 Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Pieper PG, Meijboom FJ, Groenink M, Mulder BJ, Bouma BJ.Pulmonary Valve Replacement After Repair of Pulmonary Stenosis Compared With Tetralogy of Fallot. J Am Coll Cardiol. 2016 March

8.12 Bokma JP, Mulder BJ, Bouma BJ. Letter by Bokma et al Regarding Article, "Long-Term Nationwide Follow-up Study of Simple Congenital Heart Disease Diagnosed in Otherwise Healthy Children". Circulation. 2016 Jun

 8.13 Bokma JP, de Wilde KC, Vliegen HW, van Dijk AP, van Melle JP, Meijboom FJ, Zwinderman AH, Groenink M, Mulder BJ, Bouma BJ. Value of Cardiovascular Magnetic Resonance Imaging in Noninvasive Risk Stratification in Tetralogy of Fallot. JAMA Cardiol. 2017 Feb 22.

 8.14 Bokma JP, Winter MM, Vehmeijer JT, Vliegen HW, van Dijk AP, van Melle JP, Meijboom FJ, Post MC, Zwinderman AH, Mulder BJ, Bouma BJ. QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot. Heart. 2017 May

 8.15 Bokma JP, Winter MM, Kuijpers JM, Jong-bloed MR, Duijnhouwer AL, Hoendermis ES, Sieswerda GT, Post MC, Mulder BJM, Bouma BJ. Role of Acquired Cardiovascular Disease in Tetralogy of Fallot Patients >50 Years of Age. J Am Coll Cardiol. 2017May

 

18. Prof.dr. B.J.M. Mulder, Prof. dr. A.F. Moorman, AMC Amsterdam: Heart failure and cardiac repair; genes for heart repair and plasticity

18.1.van Engelen K, Topf A, KeavneyBD, Goodship JA, van der Velde ET, Baars MJ, Snijder S, Moorman AF, Postma AV, Mulder BJ. 22q11.2 Deletion Syndrome is under-recognised in adult patients with tetralogy of Fallot and pulmonary atresia. Heart. 2010 Apr

18.2. van Engelen K, Baars MJ, van Rongen LT, van der Velde ET, Mulder BJ, Smets EM. Adults with congenital heart disease: Patients' knowledge and concerns about inheritance. Am J Med Genet A. 2011 Jun 10

18.3. J.B.A. van de Meerakker, K. van Engelen, I.B. Mathijssen, R.H. Lekanne dit Deprez, J. Lam MD, A.A.M. Wilde, M.J.H. Baars, M.M.A.M. Mannens, B.J.M Mulder, A.F.M. Moorman, A.V. Postma A novel autosomal dominant condition consisting of congenital heart defects and low atrial rhythm maps to chromosome 9q Eur J Hum Genet. 2011 Jul 19.

18.4. Klaartje van Engelen, Alex V Postma, Judith van de Meerakker, Jolien W Roos-Hesselink, Apollonia ThJM Helderman-van den Enden, Hubert W Vliegen,Thahira Rahman, Marieke JH Baars, Ulrike Bauer, Thomas Pickardt, Silke R Sperling, Antoon FM Moorman, Bernard Keavney, Judith Goodship, Sabine Klaassen, Barbara JM Mulder Ebstein anomaly may be caused by mutations in the sarcomere protein gene MYH7 Neth Heart J. 2011 May.

18.5. Klaartje van Engelen, Marieke JH Baars, Alex V Postma, Barbara JM Mulder Response to letter regarding: 22q11.2 Deletion Syndrome is under-recognised in adult patients with tetralogy of Fallot and pulmonary atresia. Heart. 2011 Mar 17.

18.6. Postma AV, van Engelen K, van de Meerakker J, Rahman T, Probst S, Baars MJ, Bauer U, Pickardt T, Sperling SR, Berger F, Moorman AF, Mulder BJ, Thierfelder L, Keavney B, Goodship J, Klaassen S. Mutations in the Sarcomere Protein Gene MYH7 in Ebstein's Anomaly. Circ Cardiovasc Genet. 2011 Feb 4.

18.7 Cordell HJ, Topf A, Mamasoula C, Postma AV, Bentham J. Zelenika D, Heath S, Blue G, Cosgrove C, Granados Riveron J, Darlay R, Soemedi R, Wilson IJ, Ayers KL, Rahman TJ, Hall D, Mulder BJ, Zwinderman AH, van Engelen K, Brook JD, Setchfield K, Bu'Lock FA, Thornborough C, O'Sullivan J, Stuart AG, Parsons J, Bhattacharya S, Winlaw D, Mital S, Gewillig M, Breckpot J, Devriendt K, Moorman AF, Rauch A, Lathrop GM, Keavney BD, Goodship JA. Genome-wide association study identifes loci on 12q24 and 13q32 associated with tetralogy of Fallot. Hum Mol Genet. 2013 Apr. 1

18.8 Cordell HJ, Bentham J, Topf A, Zelenika D, Heath S, Mamasoula C, Cosgrove C, Blue G, Granados-Riveron J, Setchfield K, Thornborough C, Breckpot J. Soemedi R, Martin R, Rahman TJ, Hall D, van Engelen K, Moorman AF, Zwinderman AH, Barnett P, Koopmann TT, Adriaens ME, Varro A, George AL Jr, dos Remedios C, Bishopric NH, Bezzina CR, O'Sullivan J, Gewillig M, Bu'Lock FA, Winlaw D, Bhattacharya S, Devriendt K, Brook JD, Mulder BJ, Mital S, Postma AV, Lathrop GM, Farrall M, Goodship JA, Keavney BD. Genome-wide association study of multiple congenital heart disease phenotypes indentifes a susceptibility locus for atrial septal defect at chromosome 4p16. Nat Genet. 2013 Jul.

18.9 Mamasoula C, Prentice RR, Pierscionek T, Pangilinan F, Mills JL, Druschel C, Pass K, Russel MW, Hall D, Topf A, Brown DL, Zelenika D, Bentham J, Cosgrove C, Bhattacharya S, Riveron JG, Setchfield K, Brook JD, Bu'Lock FA, Thornborough C, Rahman TJ, Doza JP, Than HL, O'Sullivan J, Stuart AG, Blue G, Winlaw D, Postma AV, Mulder BJ, Zwinderman AH. van Engelen K, Moorman AF, Rauch A, Gewillig M, Breckpot J. Devriendt K, Lathrop GM, Farrall M, Goodship JA, Cordell HJ, Brody LC, Keavney BD. Association between C677T Polymorphism of Methylene Tetrahydrofolate Reductase and Congenital Heart Disease: Meta-Analysis of 7697 Cases an 13 125 Controls. Circ Cardiovasc. Genet. 2013 aug.

 

25. Prof.dr. B.J.M. Mulder, Prof.dr. A.H. Zwinderman: Losartan in Marfan syndrome

25.1. Lilian J. Meijboom, Janneke Timmermans, Aeiko H. Zwinderman, Peter M. Engelfriet and Barbara J.M. Mulder. Aortic Root Growth in Men and Women with the Marfan’s Syndrome. J Cardiol. 2005 Nov 15

25.2. Meijboom LJ, Vos FE, Timmermans J, Boers GH, Zwinderman AH, Mulder BJ Pregnancy and aortic root growth in the Marfan syndrome: a prospective study. Eur Heart J. 2005 May

25.3. Meijboom LJ, Timmermans J, van Tintelen JP, Nollen GJ, De Backer J, van den Berg MP, Boers GH, Mulder BJ Evaluation of left ventricular dimensions and function in Marfan’s syndrome without significant valvular regurgitation.Am J Cardiol. 2005 March

25.4. deBackerJ , Nollen GJ, Devos D, Pals G, Coucke P, Verstraete K, van der Wall EE, Daepe A, Mulder BJ. Variability of aortic stiffness is not associated with the fibrillin 1 genotype in patients with Marfan's syndrome. Heart.2006

25.5. Engelfriet PM, Mulder BJM. Is there benefit of beta-blocking agents in the treatment of patients with the Marfan syndrome? Int J Cardiol. 2007 Jan 18;114(3):300-2. Epub 2006 Jun 12.

25.6. Radonic T, de Witte P, Groenink M, de Bruin-Bon RA, Timmermans J, Scholte AJ, van den Berg MP, Baars MJ, van Tintelen JP, Kempers M, Zwinderman AH, Mulder BJ. Critical Appraisal of the Revised Ghent Criteria for Diagnosis of Marfan Syndrome. Int J Clin Genet. 2011 Feb 17.

25.7. Radonic T, de Witte P, Baars MJ, Zwinderman AH, Mulder BJ, Groenink M; COMPARE study group. Losartan therapy in adults with Marfan syndrome: study protocol of the multi-center randomized controlled COMPARE trial. Int J Journal Date.

25.8. Radonic T, de Witte P, Groenink M, de Waard V, Lutter R, van Eijk M, Jansen M, Timmermans J, Kempers M, Scholte AJ, Hilhorst-Hofstee Y, van den Berg MP, van Tintelen JP, Pals G, Baars MJ, Mulder BJ, Zwinderman AH. Inflammation aggravates disease severity in Marfan syndrome patients. PLoS One. 2012;7. 

25.9. Hartog AW, Franken R, Zwinderman AH, Groenink M, Mulder BJ. Current and future pharmacological treatment strategies with regard to aortic disease in Marfan syndrome.. Expert Opin Pharmacother. 2012 Apr;13.

25.10 Romy Franken, Alexander W. den Hartog, Michael Singh, Gerard Pals, Aeilko H. Zwinderman, Maarten Groenink, Barbara J.M. Mulder. Marfan Syndrome: Progress Report. Progress in Pediatric Cardiology. 2012 June.

25.11 de Witte P, Aalberts JJ, Radonic T, Timmermans J, Scholte AJ, Zwinderman AH, Mulder BJ, Groenink M, van den Berg MP.Intrinsic biventricular dysfunction in Marfan syndrome. Heart. 2011 Dec.

25.12 Westenberg JJ, Scholte AJ, Vaskova Z, van der Geest RJ, Groenink M, Labadie G, van den Boogaard PJ, Radonic T, Hilhorst-Hofstee Y, Mulder BJ, Kroft LJ, Reiber JH, de Roos A. Age-related and regional changes of aortic stiffness in the marfan syndrome: Assessment with velocity-encoded MRI. J Magn Reson Imaging. 2011 Jul 14.

25.13 Radonic T, de Witte P, Baars MJ, Zwinderman AH, Mulder BJ, Groenink M. Losartan therapy in adults with Marfan syndrome: study protocol of the multi-center randomized controlled COMPARE trial. COMPARE study group. Trials. 2010 Jan 12.

25.14 Bruning O, Rodenburg W, Radonic T, Zwinderman AH, de Vries A, Breit TM, de Jong M. RNA isolation for transcriptomics of human and mouse small skin biopsies. BMC Res Notes. 2011 Oct

25.15 Franken R, den Hartog AW, de Waard V, Engele L, Radonic T, Lutter R, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Groenink M, Mulder BJ. Circulating transforming growth factor-ß as a prognostic biomarker in Marfan syndrome. Int J Cardiol. 2013 Oct. 3

 25.16  den Hartog AW, Franken R, de Witte P, Radonic T, MarqueringHA, van der Steen WE, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Mulder BJ, Groenink M. Aortic disease in patients with Marfan syndrome: Aortic volume assessment for surveillance. Radiology, 15 june 2013

25.17 Groenink M, den Hartog AW, Franken R, Radonic T. de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Spijkerboer AM, Marquering HA, Zwinderman AH, Mulder BJ. Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial. Eur Heart J. 2013 sep 2.

25.18 Franken R, den Hartog AW, van de Riet L, Timmermans J, Scholte AJ, van den Berg MP, de Waard V, Zwinderman AH, Groenink M, Yip JW, Mulder BJ. Clinical features differ substantially between caucasian and asian populations of marfan syndrome. Circ J. 2013 Oct 25.

 25.19 Franken R, den Hartog AW, Radonic T, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Mulder BJ, Groenink M. Effect of losartan treatment on aortic dilatation in adults with Marfan syndrome. Ned Tijdschr Geneeskd. 2014

25.20 Franken R, Hibender S, den Hartog AW, Radonic T, de Vries CJ, Zwinder-man AH, Groenink M, Mulder BJ, de Waard V. No beneficial effect of general and specific anti-inflammatory therapies on aortic dilatation in marfan mice. PLoS One. 2014 Sep 19;9(9):e107221.

25.21 Franken R, Radonic T, den Hartog AW, Groenink M, Pals G, van Eijk M, Lutter R, Mulder BJ, Zwinderman AH, de Waard V; COMPARE study group. The revised role of TGF-β in aortic aneurysms in Marfan syndrome.Netherlands Heart Journal 24 October 2014

25.22 Franken R, den Hartog A, Radonic T, Micha D, Maugeri A, van Dijk FS, Meijers-Heijboer HE, Timmermans J, Scholte AJ, van den Berg MP, Groenink M, Mulder BJ, Zwinderman AH, de Waard V, Pals G.Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome.. Circ Cardiovasc Genet. 2015 Jan 22.

25.23 den Hartog AW, Franken R, Zwinderman AH, Timmermans J, Scholte AJ, van den Berg MP, de Waard V, Pals G, Mulder BJ, Groenink M. The risk for type B aortic dissection in marfan syndrome. Journal of the American College of Cardiology, 27 January 2015

25.24 Franken R, El Morabit A, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Marquering H, Planken NR, Zwinderman AH, Mulder BJ, Groenink M.Increased aortic tortuosity indicates a more severe aortic phenotype in adults with Marfan syndrome. International Journal of Cardiology, 15 May 2015

25.25 Franken R, Groenink M, de Waard V,Feenstra HM, Scholte AJ, van den Berg MP, Pals G, Zwinderman AH,Timmermans J, Mulder BJ. Genotype impacts survival in Marfan syndrome.
Eur Heart J. 2016 Jan 18.

 25.26 Franken R, Mulder BJ. Aortic disease: Losartan versus atenolol in the Marfan aorta-how to treat? Nat Rev Cardiol. 2015 Jun 16.

25.27 den Hartog AW, Franken R, van den Berg MP, Zwinderman AH, Timmermans J, Scholte AJ, de Waard V, Spijkerboer AM, Pals G, Mulder BJ, Groenink M. The effect of losartan therapy on ventricular function in Marfan patients with haploinsufficient or dominant negative FBN1 mutations. Neth Heart J. 2016 Nov.24

 

 26. Dr. B.J. Bouma, Prof.dr. B.J.M. Mulder, AMC Amsterdam: Statins in Aortic Coarctation

26.1 Luijendijk P, Bouma BJ, Vriend JW, Vliegen HW, Groenink M, Mulder BJ Usefulness of exercise-induced hypertension as predictor of chronic hypertension in adults after operative therapy for aortic isthmic coarctation in childhood. Am J Cardiol. 2011 Aug 1;108(3):435-9. Epub 2011 May 6.

26.2 Luijendijk P, Boekholdt SM, Blom NA, Groenink M, Backx AP, Bouma BJ, Mulder BJ, De Winter RJ. Percutaneous treatment of native aortic coarctation in adults. Neth Heart J. 2011 Oct 19.

26.3 Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Veen G, Zwinderman AH, Mulder BJ.Rationale and design of a trial on the effect of high dose statins on cardiovascular risk in adults after successful coarctation repair. Contemp Clin Trials. 2012 Mar;33(2):410-6. Epub 2011 Nov 13.

26.4 Luijendijk P, Franken RJ, Vriend JW, Zwinderman AH, Vliegen HW, Winter MM, Groenink M, Bouma BJ, Mulder BJ. Increased risk for ascending aortic dilatation in patients with complex compared to simple aortic coarctation. Int J Cardiol. 2012 Feb 25.

26.5 Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Spijkerboer AM, Mulder BJ. Left ventricular fibrosis in adults after coarctation repair, does it play a role? Int J Cardiol. 2013, july 26

26.6 Luijendijk P, Stevens AW, de Bruin-Bon RH, Boekholdt SM, Vriend JW, Vliegen HW, Bouma BJ, Mulder BJ. Rates and determinants of progressive aortic valve dysfunction in aortic coarctation. Int J Cardiol,. 2013 sept. 10

 26.7 Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Konings TC, Stroes ES, Zwinderman AH, Mulder BJ. Beneficial effect of high dose statins on the vascular wall in patients with repaired aortic coarctation. Int. J. Cardiol. 2014 sept.

26.8 Luijendijk P, Lu H, Heynneman FB, Huijgen R, de Groot EE, Vriend JW, Vliegen HW, Groenink M, Bouma BJ, Mulder BJ. Increased carotid intima-media thickness pre-dicts cardiovascular events in aortic coarctation.Int J Cardiol. 2014 Oct 20

28. Dr. B.J.Bouma, Prof.dr. B.J.M. Mulder: Angiotensin II receptor blockers in patients with a systemic right ventricle

28.1. Winter MM, Bernink FJ, Groenink M et al. Evaluating the systemic right ventricle by CMR: the importance of consistent and reproducible delineation of the cavity. J Cardiovasc Magn Reson 2008

28.2. Winter MM, Bouma BJ, van Dijk AP et al. Relation of physical activity, cardiac function, exercise capacity, and quality of life in patients with a systemic right ventricle. Am J Cardiol 2008 November 1

28.3. Winter MM, van der Plas MN, Bouma BJ, Groenink M, Bresser P, Mulder BJ. Mechanisms for cardiac output augmentation in patients with a systemic right ventricle. Int. J.Cardiol 2009 February 22.

28.4. Winter MM, Mulder BJ, van der Velde ET. Letter by Winter et al regarding article: Children and adults with congenital heart disease lost to follow-up: who and when? Circulation. 2010 Mar 30

28.5. Winter MM, Reisma C, Kedde H, Bouma BJ, Vis JC, Luijendijk P, de Witte P, Zwinderman AH, Vliegen HW, Pieper PG, van Dijk AP, Mulder BJ. Sexuality in adult patients with congenital heart disease and their partners. Am J Cardiol. 2010 Oct 15

28.6. Winter MM, Scherptong RW, Kumar S, Bouma BJ, Tulevski II, Tops LF, Roest AA, Vliegen HW, de Roos A, Groenink M, Mulder BJ. Ventricular response to stress predicts outcome in adult patients with a systemic right ventricle. Am Heart J. 2010 Nov

28.7. van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesslink JW, Zwinderman AH, Mulder BJ. Rationale and design of a trial on the effect of angiotensin II receptor blockers on the function of the systemic right ventricle. Am Heart J. 2010 Nov

28.8. van der Bom T, Zomer AC, Zwinderman AH, Meijboom FJ, Bouma BJ, Mulder BJ. The changing epidemiology of congenital heart disease. Nat Rev Cardiol. 2011 Jan

28.9. van der Bom T, Luijendijk P, Bouma BJ, Koolbergen DR, de Groot JR, Mulder BB. Treatment of congenital heart disease: risk-reducing measures in young adults. Future Cardiol. 2011 March

28.10. Winter MM, van der Bom T, de Vries LC, Balducci A, Bouma BJ, Pieper PG, van Dijk AP, van der Plas MN, Picchio FM, Mulder BJ. Exercise training improves exercise capacity in adult patients with a systemic right ventricle: a randomized clinical trial. Eur Heart J. 2011 Oct 27

28.11 van der Bom T, Bouma BJ, Meijboom FJ, Zwinderman AH, Mulder BJ. The prevalence of adult congenital heart disease, results from a systematic review and evidence based calculation. Am Heart J. 2012

28.12 van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-
Hesselink JW, Zwinderman AH, Mulder BJ.
The Effect of Valsartan on the Systemic Right Ventricular Function: A Double-Blind Randomized Placebo-Controlled Pilot Trial. Circulation. 2012 Dec 17. 

28.13  van der Bom T, Winter MM, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, Mulder BJ, Bouma BJ. J Am Coll Cardiol. Right ventricular end-diastolic volume combined with peak systolic blood pressure during exercise identifies patients at risk of complications in adults with a systemic right ventricle. 2013 Sept.

28.14 van der Bom T, Romeih S, Groenink M, Pieper PG, van Dijk AP, Helbing WA, Zwinderman AH, Mulder BJ, Bouma BJ. Evaluating the Systemic Right Ventricle by Cardiovasculair Magnetic Resonance: Short Axis or Axial slices? Cong. Heart Dis. 2014 April 21

28.15 van der Bom T, Winter MM, Knaake JL, Cervi E, de Vries LS, Balducci A, Meregalli PG, Pieper PG, van Dijk AP, Bonvicini M, Mulder BJ, Bouma BJ.Long-term benefits of exercise training in patients with a systemic right ventricle.Int J Cardiol. 2015 Jan

 31.Dr. P.G.Pieper, UMCG Groningen: Pregnancy in congenital heart disease (ZAHARA2+ZAHARA3)

31.1. Balci A, Drenthen W, Mulder BJ, Roos-Hesselink JW, Voors AA, Vliegen HW, Moons P, Sollie KM, van Dijk AP, van Veldhuisen DJ, Pieper PG.Pregnancy in women with corrected tetralogy of Fallot:  occurrence and predictors of adverse events. Am Heart J. 2011 Feb;161(2):307-13. Epub 2011 Jan 15.

31.2. Balci A, Sollie KM, Mulder BJ, de Laat MW, Roos-Hesselink JW, van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, van Veldhuisen DJ, Pieper PG. Associations between cardiovascular parameters and uteroplacental Doppler (blood) flow patterns during pregnancy in women with congenital heart disease: Rationale and design of the Zwangerschap bij Aangeboren Hartafwijking (ZAHARA) II study. Am Heart J. 2011 Feb.

31.3 Drenthen W, Boersma E, Balci A, Moons P, Roos-Hesselink JW, Mulder BJ, Vliegen HW, van Dijk AP, Voors AA, Yap SC, van Veldhuisen DJ, Pieper PG, ZAHARA Investigators. Predictors of pregnancy complications in women with congenital heart disease. Eur Heart J. 2010 Sep

31.4 Pieper PC, Balci A, Aarnoudse JG, Kampman MA, Sollie KM, Groen H, Mulder BJ, Oudijk MA, Roos-Hesslink JW, Cornette J, van Dijk AP, Spaanderman ME, Drenthen W, van Veldhuisen DJ. Uteroplacental Blood Flow, Cardiac Function and Pregnancy Outcome in Women with Congenital Heart Disease. On behalf of the ZAHARA II investigators. Circulation  2013 NOV 5.

31.5 Kampman MA, Balci A, van Veldhuisen DJ, van Dijk AP, Roos-Hesselink JW, Sollie-Szarynska KM, Ludwig-Ruitenberg M, van Melle JP, Mulder BJ, Pieper PG; on behalf of the ZAHARA II investigators.           N-terminal pro-B-type natriuretic peptide predicts cardiovasculair complications in pregnant women with congenital heart disease. Eur Heart J. 2013 dec 13.

 31.6 Balci A, Sollie-Szarynska KM, van der Bijl AG, Ruys TP, Mulder BJ, Roos-Hesselink JW, van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, van Veldhuisen DJ, Pieper PG. On behalf of the ZAHARA II investigators .Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease. Heart, 2014 sept.

31.7  Kampman MA, Balci A, Groen H, van Dijk AP, Roos-Hesselink JW, van Melle JP, Sol-lie-Szarynska KM, Wajon EM, Mulder BJ, van Veldhuisen DJ, Pieper PG; ZAHARA II investi-gators. Cardiac function and cardiac events 1-year postpartum in women with congenital heart disease. Am Heart J. 2015 Feb

31.8 Kampman MA, Valente MA, van Melle JP, Balci A, Roos-Hesselink JW, Mulder BJ, van Dijk AP, Oudijk MA, Jongbloed MR, van Veldhuisen DJ, Pieper PG; ZAHARA II investigators.Cardiac adaption during pregnancy in women with congenital heart disease and healthy women..Heart. 2016 Aug 15

31.9 Kampman MA, Siegmund AS, Bilardo CM, van Veldhuisen DJ, Balci A, Oudijk MA, Groen H, Mulder BJ, Roos-Hesselink JW, Sieswerda G, de Laat MW, Sollie-Szarynska KM, Pieper PG;Uteroplacental Doppler flow and pregnancy outcome in women with tetralogy of Fallot.ZAHARA investigators..Ultrasound Obstet Gynecol. 2017 Feb

32. Prof. dr. B.J. Mulder, prof. dr. I.C. van Gelder, UMCG, dr. Z. Koyak: Arrhythmias in adults with CHD

32.1. Koyak Z, de Groot JR, Mulder BJ. Interventional and surgical treatment of cardiac arrhythmias in adults with congenital heart disease. Expert Rev Cardiovasc Ther. 2010 Dec;8(12):1753-66.

32.2. Koyak Z, de Groot JR, Van Gelder IC, Bouma BJ, van Dessel PF, Budts W, van Erven L, van Dijk AP, Wilde AA, Pieper PG, Sieswerda GT, Mulder BJ.Implantable Cardioverter Defibrillator Therapy in Adults with Congenital Heart Disease: Who is at Risk of Shocks? Circ Arrhythm Electrophysiol. 2011 Nov 17.

32.3 Valente AM, Gauvreau K, Assenza GE, Babu-Narayan SV, Evans SP, Gatzoulis M, Groenink M, Inuzuka R, Kilner PJ, Koyak Z, Landzberg MJ, Mulder B, Powell AJ, Wald R, Geva T. Rationale and Design of an International Multicenter Registry of Patients With Repaired Tetralogy of Fallot to Define Risk Factors for Late Adverse Outcomes: The INDICATOR Cohort. Pediatr Cardiol. 2012 Jun 5.

32.4 Koyak Z, de Groot JR, Bouma BJ, Van Gelder IC, Budts W, Zwinderman AH, Mulder BJ. Symptomatic but not asymptomatic non-sustained ventricular tachycardia is associated with appropriate implantable cardioverter therapy in tetralogy of Fallot. Int J Cardiol. 2013 Aug.20

32.5 Koyak Z, Harris L, de Groot JR, et al. Sudden cardiac death in adult congenital heart disease. Circulation. 2012; 126: 1944-1954. 

32.6 Koyak Z, Achterbergh RC, de Groot JR, Berger F, Koolbergen DR, Bouma BJ, Lagrand WK, Hazekamp MG, Blom NA, Mulder BJ. Postoperative arrhythmias in adults with congenital heart disease: Incidence and risk factors. Int J Cardiol. 2013 okt 30.

32.7 Koyak Z, Kroon B, de Groot JR, Wagenaar LJ, van Dijk AP, Mulder BA, van Gelder IC, Post MC, Mulder BJ, Bouma BJ. Efficacy of antiarrhythmic drugs in adults with congential heart disease and supraventricular tachycardias. AM J Cardiol. 2013 Nov 1 

32.8 Koyak Z, de Groot JR, Krimly A, Mackay TM, Bouma BJ, Silversides CK, Oechslin EN, Hoke U, van Erven L, Budts W, Van Gelder IC, Mulder BJ, Harris L. Cardiac resynchronization therapy in adults with congenital heart disease. Europace. 2017 Jan

 32.9 Koyak Z, de Groot JR, Bouma BJ, Zwinderman AH, Silversides CK, Oechslin EN, Budts W, Van Gelder IC, Mulder BJ, Harris L. Sudden cardiac death in adult congenital heart disease: can the unpredictable be foreseen? Europace. 2017 Mar 1

 

35. Prof. dr. B.J.M. Mulder, Dr. K.v.Engelen, Dr. A.V. Postma; AMC Amsterdam: GATA5 a new congenital heart defect gene

 36. Prof. dr. B.J.M. Mulder, Dr. B.J.  Bouma, AMC Amsterdam: Right sided CHD

36.1 Schuuring MJ, Vis JC, Duffels MG, Bouma BJ, Mulder BJ. Adult patients with pulmonary arterial hypertension due to congenital heart disease: a review on advanced medical treatment with bosentan. Ther Clin Risk Manag. 2010

36.2 Schuuring MJ, Bolmers PP, Mulder BJ, de Bruin-Bon RA, Koolbergen DR, Hazekamp MG, Lagrand WK, De Hert SG, de Beaumont EM, Bouma BJ.Right ventricular function declines after cardiac surgery in adult patients with congenital heart disease. Journal and Date. 

36.3 Schuuring MJ, Vis JC, Bouma BJ, van Dijk AP, van Melle JP, Pieper PG, Vliegen HW, Sieswerda GT, Mulder BJ. Rationale and design of a trial on the role of bosentan in Fontan patients: Improvement of exercise capacity? Journal and Date.

36.4 Schuuring MJ, Boekholdt SM, Windhausen A, Bouma BJ, Groenink M, Keijzers M, De Winter RJ, Koolbergen DR, Blom NA, Mulder BJ. Advanced therapy for ulmonary arterial hypertension due to congenital heart disease: a clinical perspective in a new therapeutic era. Neth Heart J. 2011 Nov 16.

36.5 Schuuring MJ, van Riel AC, Bouma BJ, Mulder BJ. Recent progress in treatment of pulmonary arterial hypertension due to congenital heart disease. Neth Heart J. 2011 Nov 12.

36.6 Schuuring MJ, van Riel AC, Vis JC, Duffels MG, van Straalen JP, Boekholdt SM, Tijssen JG, Mulder BJ, Bouma BJ. High-sensitivity Troponin T Is Associated with Poor Outcome in Adults with Pulmonary Arterial Hypertension due to Congenital Heart Disease. Congenit Heart Dis. 2012 Dec 14.

36.7 Schuuring MJ, Bouma BJ, Cordina R, Gatzoulis MA, Budts W, Mullen MP, VisJC, Celermajer D, Mulder BJ. Treatment of segmental pulmonary artery hypertension in adults with congenital heart disease. Int J Cardiol. 2013 Mar 20;164(1):106-10 Epub 2011 Jul 18.

36.8  Schuuring MJ, Vis JC, van Dijk AP, van Melle JP, Vliegen HW, Pieper PG, Sieswerda GT, de Bruin-Bon RH, Mulder BJ, Bouma BJ. Eur J Heart Fail. 2013 Jun. Impact of bosentan on exercise capacity in adults after the Fontan procedure: a randomized controlled trial.

36.9 Schuuring MJ, van Gulik EC, Koolbergen DR, Hazekamp MG, Lagrand WK, Backx AP, Mulder BJ, Bouma BJ.  Determinants of clinical right ventriicular failure after congenital heart surgery in adults. J Cardiothorac Vasc Anesth 2013 aug.27

36.10 Blok IM, van Riel AC, Schuuring MJ, Duffels MG, Vis JC, van Dijk AP, Hoendermis ES, Mulder BJ, Bouma BJ. Decrease in quality of life predicts mortality in adult patients with pulmonary arterial hypertension due to congenital heart disease. Netherlands Heart Journal, May 2015

 36.11 Blok IM, van Riel AC, Mulder BJ, Bouma BJ.Management of patients with pulmonary arterial hypertension due to congenital heart disease: recent advances and future directions.Expert review of cardiovascular therapy, 16 October 2015

36.12  Blok IM, van Riel AC, Schuuring MJ, de bruin-Bon RH, van Dijk AP, Hoendermis ES, Zwinderman AH, Mulder BJ, Bouma BJ. The role of cystatin C as a biomarker for prognosis in pulmonary arterial hypertension due .Int J Cardiol. 2016 Apr

36.13 Blok IM, van Riel AC, van Dijk AP, Mulder BJ, Bouma BJ. From bosentan to maciten-tan for pulmonary arterial hypertension and adult congenital heart disease: Furt-her improvement? Int J Cardiol. 2017 jan 15

36.14 van Dissel AC, Mulder BJ, Bouma BJ The Changing Landscape of Pulmonary Arterial Hypertension in the Adult with Congenital Heart Disease..J Clin Med. 2017 March

 

 37.Dr. D. Schoormans, AMC Amsterdam: Predicting health care use and perceived health care needs in patients with congenital disease.

37.1. Schoormans D, Sprangers MA, Pieper PG, van Melle JP, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ. The Perspective of Patients with Congenital Heart Disease: Does Health Care Meet Their Needs? Congenit Heart Dis. 2011 May;6  Epub 2011 May 5.

37.2 Schoormans D, Mager YL, Oort FJ, Sprangers MA, Mulder BJ. New York Heart Association class assessment by cardiologists and outpatients with congenital cardiac disease: a head-to-head comparison of three patient-based versions. Cardiol Young. 2012 Feb;22(1):26-33. Epub 2011 Jul 4.

37.3 Schoormans D, Mulder BJ, Sprangers MA. Letter by Schoormans et al. regarding article: Recommendations for improving the quality of interdisciplinary care of grown-up with congenital heart disease (GUCH). 

37.4 Schoormans D, Radonic T, de Witte P, Groenink M, Azim D, Lutter R, Mulder BJ, Sprangers MA, Zwinderman AH. Mental quality of life is related to a cytokine genetic pathway. PLoS One. 2012;7(9):e45126. Epub 2012

37.5 Schoormans D, Smets EM, Zwart R, Sprangers MA, Veelenturg TH, de Mol BA, Hazekamp MG, Koolbergen DR, Sojak V, Bouma BJ, Groenink M, Boekholdt MS, Backx AP, Mulder BJ. Peri-operative care in adults with congenital heart disease: room for improvement in after care. Oct 2, 2012

37.6 Schoormans D, Sprangers MA, Budts W, Mulder BJ, Apers S, Moons P. Erratum to: Perceived health is partially associated with the symptomatological profile in patients with benign and severe conditions: the case of congenital heart disease. Oct 23, 2012

37.7 Schoormans D, Mulder BJ, van Melle JP, Pieper EG, van Dijk AP, Sieswerda GJ, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Sprangers MA. Patients with a congenital heart defect and type D personality feel functionally more impaired, report a poorer health and quality of life, but use less healthcare

37.8  Schoormans D, Mulder BJ, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Sprangers MA. Illness perceptions of adults with congenital heart disease and their predictive value for quality of life two years later. Eur J Cardiovasc Nurs. 2013 Mar 22. PMID: 23524630.

37.9  Schoormans D, Sprangers MA, Mulder BJ. Future challenges in providing appropriate care for adults with congenital heart disease. Int J Cardiol. 2013 Oct.3

37.10  Schoormans D, Sprangers MA, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ. Clinical and psychological characteristics pre-dict future healthcare use in adults with con-genital heart disease.Eur J Cardiovasc Nurs. 2014 Oct 20.

37.11 Schoormans D, Wierenga EA. Are adults with congenital heart disease at risk for the development of heart failure when feeling depressed? An immunological mechanism. Pediatr Cardiol. 2012 Oct; Epub 2012 May 26.

 

38. Prof. dr. B.J.M. Mulder, AMC Amsterdam: Facing the future of adults with congenital heart disease

38.1 Zomer AC, Uiterwaal CS, der Velde ET, Tijssen JG, Mariman EC, Verheugt CL, Vaartjes I, Pieper PG, Meijboom FJ, Grobbee DE, Mulder BJ. Mortality in adult congenital heart disease: Are national registries reliable for cause of death? Int J Cardiol. 2010 July

38.2 Zomer AC, Vaartjes I, Uiterwaal CS, van der Velde ET, van den Merkhof LF, Baur LH, Ansink TJ, Cozijnsen L, Pieper PG, Meijboom FJ, Grobbee DE, Mulder BJ. Circumstances of death in adult congenital heart disease. Int J Cardiol. 2010 Oct.

38.3 Zomer AC, Verheugt CL, Vaartjes I, Uiterwaal CS, Langemeijer MM, Koolbergen DR, Hazekamp MG, van Melle JP, Konings TC, Bellersen L, Grobbee DE, Mulder BJ. Surgery in Adults With Congenital Heart Disease. Circulation. 2011 Oct.

38.4 Zomer AC, Vaartjes I, Grobbee DE, Mulder BJ. Adult congenital heart disease: New challenges. Int J Cardiol. 2012 Mar.

38.5 Zomer AC, Vaartjes I, Uiterwaal CS, van der Velde ET, Sieswerda GJ, Wajon EM, Plomp K, van Bergen PF, Verheugt CL, Krivka E, de Vries CJ, Lok DJ, Grobbee DE, Mulder BJ. Social burden and lifestyle in adults with congenital heart disease. Am J Cardiol. 2012 Jun; Epub 2012 Mar.

38.6 van der Bom T, Zomer AC, Zwinderman AH, Meijboom FJ, Bouma BJ, Mulder BJ. The changing epidemiology of congenital heart disease. Nat Rev Cardiol. 2011 Jan.

38.7 A.C. Zomer, I. Vaartjes, E.T. van der Velde, H.M. de Jong, T.C. Konings, L.J. Wagenaar,W.F. Heesen, F. Eerens, L.H. Baur, D.E. Grobbee, B.J. Mulder.International Journal of Cardiology, April 2013 Heart failure admissions in adults with congenital heart disease; risk factors and prognosis.

38.8 Zomer AC, Ionescu-Ittu R, Vaartjes I, Pilote L, Mackie AS, Therrien J, Langemeijer MM, Grobbee DE, Mulder BJ, Marelli AJ; Sex differences in hospital Mortuality in Adults with Congenital Heart Disease: The impact of Reproductive Health. Journal of the American College of Cardiology,  july 2013

38.9 Kuijpers JM, Mulder BJ, Bouma BJ.Secundum atrial septal defect in adults: a practical review and recent developments. Netherlands Heart Journal, 23 April 2015

38.10 Kuijpers JM, van der Bom T, van Riel AC, Meijboom FJ, van Dijk AP, Pieper PG, Vliegen HW, Waskowsky WM, Oomen T, Zomer AC, Wagenaar LJ, Heesen WF, Roos-Hesselink JW, Zwinderman AH, Mulder BJ, Bouma BJ.Secundum atrial septal defect is associated with reduced survival in adult men.European Heart Journal, 16 April 2015

38.11 Kuijpers JM, Koolbergen DR, Groenink M, Peels KC, Reichert CL, Post MC, Bosker HA, Wajon EM, Zwinderman AH, Mulder BJ, Bouma BJ. Incidence, risk factors, and predictors of infective endocarditis in adult congenital heart disease: focus on the use of prosthetic material. Eur Heart J. 2017 Jan 8.

 38.12 Kuijpers JM, Mulder BJ. Aorto-pathies in adult congenital heart disease and genetic aortopathy syndromes: management strategies and indications for surgery. Heart. 2017 Mar 7.

 

39. Prof. dr. P. Doevendans UMC Utrecht: Genomics of the arterial pole

39.1 Joziasse IC, Vink A, Cramer MJ, van Oosterhout MF, van Herwerden LA, Heijmen R, Sieswerda GT, Mulder BJ, Doevendans PA. Bicuspid stenotic aortic valves: clinical characteristics and morphological assessment using MRI and echocardiography. Neth Heart J. 2011 Mar;19(3):119-125. Epub 2011 Feb.  

40.Dr. P.G. Pieper UMC Groningen: Functional outcome and quality of life in adult congenital heart disease patients with prosthetic valves

40.1 Freling HG, van Slooten YJ, van Melle JP, Mulder BJ, van Dijk AP, Hillege HL, Post MC, Sieswerda GT, Jongbloed MR, Willems TP, Pieper PG; On behalf of the PROSTAVA investigators. Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study.Neth Heart J. 2012 Oct;20(10) 

 40.2  van Slooten YJ, Freling HG, van Melle JP, Mulder BJ, Jongbloed MR, Ebels T, Voors AA, Pieper PG; Long-term tricuspid valve prothesis-related complications in patients with congenital heart disease. Eur J Cardiothorac Surg. 2013 May 17.

41. Prof. dr. B.J. Mulder, drs. A.C.M.J. v Riel, AMC Amsterdam: Epidemiology and early detection of PAH in CHD.

 41.1 van Riel AC, Schuuring MJ. van Hessen ID. Zwindermans AH, Cozijnsen L, Reichert CL, Hoorntje JC, Wagenaar LJ, Post MC, van Dijk AP, Hoendermis ES, Mulder BJ, Bouma BJ. Contempory prevalence of pulmonary arterial hypertension in adult congenital heart disease following the updated clinical classification. Int. J. Cardiol. 2014 june

 41.2 van Riel AC, de Bruin-Bon RH, Gertsen EC, Blok IM, Mulder BJ, Bouma BJ. Simple stress echocardiography unmasks early pulmonary vascular disease in adult congenital heart disease. Int J Cardiol. 2015 Jun

 41.3 van Riel AC, Blok IM, Zwinderman AH, Wajon EM, Sadee AS, Bakker-de Boo M, van Dijk AP, Hoendermis ES, Riezebos RK, Mulder BJ, Bouma BJ.Lifetime Risk of Pulmonary Hypertension for All Patients After Shunt Closure.J Am Coll Cardiol. 2015-9

41.4 van Riel AC, Schuuring MJ, van Hessen ID, van Dijk AP, Hoendermis ES, Yip JW, Mulder BJ, Bouma BJ.Treatment of pulmonary arterial hypertension in congenital heart disease in Singapore versus the Netherlands: age exceeds ethnicity in influencing clinical outcome. Neth Heart J. 2016 Jun

41.5 van Riel AC, Systrom DM, Oliveira RK, Lan-dzberg MJ, Mulder BJ, Bouma BJ, Maron BA, Shah AM, Waxman AB, Opotowsky AR. Development of a Right Ventricular Outflow Tract Gradient During Upright Exercise: A Hemodynamic Observation. J Am Coll Cardiol. 2017 Feb 7

41.6 van Riel AC, Opotowsky AR, Santos M, Rivero JM, Dhimitri A, Mulder BJ, Bouma BJ, Landzberg MJ, Waxman AB, Systrom DM, Shah AM.Accuracy of Echocardiography to Estimate Pulmonary Artery Pressures With Exercise: A Simultaneous Invasive-Noninvasive Comparison. Circ Cardiovasc Imaging. 2017 April

 42. Prof. dr. V.M. Christoffels, AMC Amsterdam: Dital deletions in 22q11.2 in tetralogie of Fallot

 43. Prof. dr. V.M. Christoffels, AMC Amsterdam: Identifying mutations in WPW patients

 44.Prof. dr. Y.M. Pinto, AMC Amsterdam: Identification of New Genes in TGA and CCTGA using Whole Exome Sequencing

 45.  Seema Mital, Toronto, Prof.dr.  B.J.M. Mulder, AMC Amsterdam: Genomic basis of Atrioventricular Septal defect

 46.Dr. J. van Melle, UMC Groningen:Congenitale vaatringen

 47. Prof. dr. B.J. Mulder, dr. M.A. Sluman, AMC Amsterdam:Socio-economic outcomes of congenital heart disease.

47.1  Sluman MA, Zomer AC, Vaartjes I, Bouma BJ, Mulder BJ. Congenital Heart Disease may hurt men more than woman in job participation. Int J Cardiol. 2014 March 1

47.2  Sluman MA, de Man S, Mulder BJ, Sluiter JK. Occupational challenges of young adult patients with congenital heart disease. Neth Heart J. 2014 Feb.22

 47.3 Sluman MA, Apers S,Bouma BJ, van Melle JP, Peels CH, Post MC,Waskowsky WM, Moons P, Mulder BJ. Uncertainties in insurances for adults with congenital heart disease. Int JCardiol. 2015 May 1

47.4 Sluman MA, Richard E, Bouma BJ, van Dalen JW, van Wanrooij LL, Groenink M, Caan MWA, Nederveen AJ, Mutsaerts HMM, Ma-joie CBLM, Schmand BA, Mulder BJM. Impact of Structural Cerebral Damage in Adults With Tetralogy of Fallot. Circulation. 2017 May 9

 

48. Prof. dr. B.J. Mulder, drs. H. Yang, AMC Amsterdam: The spectrum of atrial tachyarrhytmia's in adult congenital heart disease

48.1 Yang H, Nassif M, Khairy P, de Groot JR, Roos YB, de Winter RJ, Mulder BJ, BoumaBJ. Cardiac diagnostic work-up of ischaemic stroke. Eur Heart J. 2016 Nov 10

 

49.Prof. dr. C.R. Bezzina, Dr. A.V. Postma, AMC Amsterdan: Identifying novel genes in patients with (non-syndromic) outflow tract defects

50.Dr. M.J.B. van den Hoff, Dr. A.V. Postma, AMC Amsterdam: Identifying mutation in the Follistatin-like I locus in patients with mitral valve prolaps

 51. Dr. J. de Groot, drs. J. Vehmeijer, AMC Amsterdam: SCN5A mRNA splicing variants and sudden cardiac death in adults with congenital heart disease

 51.1 Vehmeijer JT, Koyak Z, Bokma JP, Budts W, Harris L, Mulder BJ, de Groot JR. Sudden cardiac death in adults with congenital heart disease: does QRS-complex fragmentation discriminate in structurally abnormal hearts?.Europace. 2017 Apr 10

 

De onderzoeksprojecten in lichtgrijs zijn momenteel inactief

1. Dr. P.G. Pieper, UMCG, Groningen: Pregnancy in congenital heart disease

1.1. Drenthen W, Pieper PG, Ploeg M, Voors AA, Roos-Hesselink JW, Mulder BJ, Vliegen HW, Sollie KM, Ebels T, van Veldhuisen D. Risk of complications during pregnancy after Senning or Mustard (atrial) repair of complete transposition of the great arteries. Eur Heart J. 2005 Dec.

1.2. Drenthen W, Pieper PG, van der Tuuk K, Roos-Hesselink JW, Voors AA, Mostert B, Mulder BJ, Moons P, Ebels T, van Veldhuisen DJ. Cardiac complications relating to pregnancy and recurrence of disease in the offspring of women with atrioventricular septal defects. Eur Heart J. 2005 Aug 17

1.3. Vriend JW, Drenthen W, Pieper PG, Roos-Hesselink JW, Zwinderman AH, van Veldhuisen DJ, Mulder BJ. Outcome of pregnancy in patients after repair of aortic coarctation. Eur Heart J. 2005

1.4. Meijer JM, Pieper PG, Drenthen W, Voors AA, Roos-Hesselink JW, van Dijk AP, Mulder BJ, Ebels T, van Veldhuisen DJ. Pregnancy, fertility, and recurrence risk in corrected tetralogy of Fallot. Heart. 2005 Jun.

1.5. Meijboom LJ, Drenthen W, Pieper PG, Groenink M, Post van der JAM, Timmermans J, Voors AA, Roos-Hesselink JW, Veldhuisen van DJ,Mulder BJM.Obstetric complications in the Marfan syndrome. Int J Cardiol. 2006

1.6. Drenthen W, Pieper PG, Roos-Hesselink JW, Zoon N, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Sollie KM, Ebels T, van Veldhuisen DJ; ZAHARA Investigators. Fertility, pregnancy, and delivery after biventricular repair for pulmonary atresia with an intact ventricular septum. Am J Cardiol. 2006 Jul.

1.7. Drenthen W, Pieper PG, Roos-Hesselink JW, van Lottum WA, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Sollie KM, Moons P, Ebels T, van Veldhuisen DJ; ZAHARA Investigators. Pregnancy and delivery in women after Fontan palliation. Heart. 2006 Sep.

1.8. Drenthen W, Pieper PG, Roos-Hesselink JW, Schmidt AC, Mulder BJ, van Dijk AP, Vliegen HW, Sollie KM, Voors AA, Ebels T, van Veldhuisen DJ; ZAHARA investigators. Non-cardiac complications during pregnancy in women with isolated congenital pulmonary valvar stenosis. Heart 2006 Dec.

1.9. Drenthen W, Pieper PG, Zoon N, Roos-Hesselink JW, Voors AA, Mulder BJ, van Dijk AP, Sollie KM, Vliegen HW, Ebels T, van Veldhuisen DJ; ZAHARA Investigators. Pregnancy after biventricular repair for pulmonary atresia with ventricular septal defect. Am J Cardiol. 2006 Jul.

1.10. Drenthen W, Pieper PG, Roos-Hesselink JW, Zoon N, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Sollie KM, Ebels T, van Veldhuisen DJ; ZAHARA Investigators. Fertility, pregnancy, and delivery after biventricular repair for pulmonary atresia with an intact ventricular septum. Am J Cardiol. 2006 Jul.

1.11. Drenthen W, Pieper PG, Roos-Hesselink JW, van Lottum WA, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Yap SC, Moons P, Ebels T, van Veldhuisen DJ; ZAHARA Investigators.Outcome of pregnancy in women with congenital heart disease: a literature review. J Am Coll Cardiol. 2007 Jun 19

1.12. Drenthen W, Pieper PG, van der Tuuk K, Roos-Hesselink JW, Hoendermis ES, Voors AA, Mulder BJ, van Dijk AP, Yap SC, Vliegen HW, Moons P, Ebels T, van Veldhuisen DJFertility, Pregnancy and Delivery in Women after Biventricular Repair for Double Outlet Right Ventricle.Cardiology. 2007 Aug.

1.13. Yap SC, Drenthen W, Pieper PG et al. Risk of complications during pregnancy in women with congenital aortic stenosis. Int J Cardiol 2008 May

1.14. Drenthen W, Hoendermis ES, Moons P et al. Menstrual cycle and its disorders in women with congenital heart disease. Congenit Heart Dis 2008 July

1.15. Yap SC, Drenthen W, Pieper PG et al. Outcome of pregnancy in women after pulmonary autograft valve replacement for congenital aortic valve disease. J Heart Valve Dis 2007 July

1.16. Drenthen W, Pieper PG, Roos-Hesselink JW et al. Outcome of pregnancy in women with congenital heart disease: a literature review. J Am Coll Cardio2007

2. Dr. H.L. Tan, AMC Amsterdam: Genetic basis of cardiac malformations

3. Prof. dr.  JW Roos – Hesselink, Erasmus MC Rotterdam: Molecular etiology LVOT obstruction

4. Prof. dr.  JW Roos - Hesselink, ErasmusMC, Rotterdam: Follow-up patients with an AICD.

4.1. Sing-Chien Yap, Jolien W. Roos-Hesselink, Elke S. Hoenermis, Werner Budts, Hubert W.Vliegen, Barbara J.M. Mulder, Arie P. van Dijk, Martin Schalij, W. Drenthen. Outcome of implantable cardioverter defibrillators in adults with congenital heart disease: a multi-centre study. Eur Heart J. 2007 Aug.

5. Drs. M. Kriek, LUMC Leiden:  Identification of genes involved in congenital heart malformations

6. Dr. R.H. Lekanne Deprez, AMC Amsterdam: Genetic basis of congenital cardiac malformations

7. Prof. dr. K. Devriendt, KU Leuven, Belgium: PA26, candidategen heterotaxia

9. Dr. A.V. Postma, AMC Amsterdam: GATA4 polymorphisms in congenital heart disease

10. Dr. J. Bakkers, Hubrecht Laboratorium Utrecht: From zebrafish to man: Mutation discovery in genes required for normal cardiac development

11. Prof. dr. J.W. Roos-Hesselink, Erasmus MC, Rotterdam: Prospective randomised multicentre study: statines and aortic stenosis

12. Prof. dr. R.Berger , UMCG, Groningen: TGF-ß receptor mutations in ASD

13. Prof. dr. B.J.M. Mulder, AMC, Amsterdam: Pulmonary arterial hypertension

13.1. Duffels MGJ, Engelfriet PM, Berger RMF, van Loon RLE, Hoendermis E, Vriend JWJ, van der Velde ET, Bresser P, Mulder BJM. Pulmonary arterial hypertension in congenital heart disease: An epidemiologic perspective from a Dutch registry. Int J Cardiol 2007 Aug.

13.2. M.G.J. Duffels, R.M.F. Berger, P. Bresser, H.A.C.M. de Bruin-Bon, E. Hoendermis, B.J. Bouma, B.J.M. Mulder. Applicability of bosentan in Dutch patients with Eisenmenger syndrome: preliminary results on safety and exercise capacity. Neth Heart J. 2006 May

13.3. van Loon RL, Hoendermis ES, Duffels MG, Vonk-Noordegraaf A, Mulder BJ, Hillege HL, Berger RM. Long-term effect of bosentan in adults versus children with pulmonary arterial hypertension associated with systemic-to-pulmonary shunt: does the beneficial effect persist? Am Heart J. 2007 Oct.

13.4. Duffels MG, Vis JC, van Loon RL et al. Down patients with Eisenmenger syndrome: Is bosentan treatment an option? Int J Cardiol 2008 June

13.5. Hamaker ME, Duffels MG, Reichert CL, Cornel JH, Mulder BJ, Umans VA. [Two patients with Eisenmenger syndrome treated with novel agents that target vasodilation of the pulmonary capillary bed]. Ned Tijdschr Geneeskd 2007 August.

13.6. van der Plas MN, Duffels MG, Ponse D, Mulder BJ, Bresser P. Bosentan in mild pulmonary hypertension. Lancet 2008 November 15;372(9652):1730

13.7. Duffels MG, Vis JC, van Loon RL et al. Effect of bosentan on exercise capacity and quality of life in adults with pulmonary arterial hypertension associated with congenital heart disease with and without Down’s syndrome. Am J Cardiol 2009 May

13.8. Duffels MG, Mulder KM, Trip MD, de Groot E, Gort J, van Dijk AP, Hoendermis ES, Daliento L, Zwinderman AH, Berger RM, Mulder BJ. Atherosclerosis in patients with cyanotic congenital heart disease. Circ J. 2010

13.9. Mulder BJ.Changing demographics of pulmonary arterial hypertension in congenital heart disease. Eur Respir Rev. 2010 Dec 1;19(118):308-13.

13.10. Duffels M, van Loon L, Berger R, Boonstra A, Vonk-Noordegraaf A, Mulder B.Pulmonary arterial hypertension associated with a congenital heart defect: advanced medium-term medical treatment stabilizes clinical condition. Congenit Heart Dis. 2007 July

 

14. Dr. A. Hoffmann, Universiteit Basel, A multicenter retrospective analysis on cerebrovascular accidents in a population of adults with congenital heart disease.

14.1 Hoffmann A, Chockalingam P, Balint OH, Dadashev A, Dimopoulos K, Engel R, Schmid M, Schwerzmann M, Gatzoulis MA, Mulder B, Oechslin E.Cerebrovascular accidents in adult patients with congenital heart disease. Heart. 2010 Aug.

 

15. Dr A.Van Dijk , UMCN, Nijmegen: “Morbus Ebstein

16. Prof. dr. Grobbee, Dr. C.Uiterwaal, Julius Centrum, Utrecht: Prognosis in congenital heart disease

16.1. Verheugt CL, Uiterwaal CS, van der Velde ET, et al. Gender and outcome in adult congenital heart disease. Circulation 2008 July

16.2. Verheugt CL, Uiterwaal CS, Grobbee DE, Mulder BJ. Long-term prognosis of congenital heart defects: A systematic review. Int J Cardiol 2008 August.

16.3. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Veen G, Stappers JL, Grobbee DE, Mulder BJ. Turning 18 with congenital heart disease: prediction of infective endocarditis based on a large population. Eur Heart J. 2011 Jan.

16.4. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Sieswerda GT, Plokker HW, Grobbee DE, Mulder BJ. The emerging burden of hospital admissions of adults with congenital heart disease. Heart. 2010 Jun

16.5. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, van Dijk AP, Vliegen HW, Grobbee DE, Mulder BJ. Mortality in adult congenital heart disease. Eur Heart J. 2010 May

 

17. Prof. dr. BJM Mulder, AMC,Amsterdam: CVA bij ASD

17.1 Lok SI, Winkens B, Dimpoulos K et al. Recurrence of cerebrovascular events in Young adults with a secundum arterial septal defect, Int J Cardiol 2009 January 24.

19. Dr A. V. Postma: Replication cohort for SNP studies in Tetralogy of Fallot

20. Dr A. van Dijk, UMCN, Nijmegen: Exercise in Congenital heart disease

21. Dr. Postma AMC,Amsterdam, Denmark: Genes in Aortic Stenosis

22. Prof . dr. AAM Wilde, AMC, Amsterdam: Sodium channels in septal defects

23. Prof . dr. BJM Mulder, AMC, Amsterdam: Congenital heart defects inDown syndrome

23.1. Vis JC, de Bruin-Bon RH, Bouma BJ, Huisman SA, Imschoot L, van den Brink K, Mulder BJ. Congenital heart defects are under-recognised in adult patients with Down's syndrome. Hearts. 2010 Sep.

23.2. Vis JC, Thoonsen H, Duffels MG, de Bruin-Bon RA, Huisman SA, van Dijk AP, Hoendermis ES,Berger RM, Bouma BJ, Mulder BJ. Six-minute walk test in patients with Down syndrome: validity and reproducibility.Arch Phys Med Rehabil. 2009

 

24. Seshadri Balaji, Maully Shah, Dr. Roos-Hesselink Philadelphia/Rotterdam, Arrhythmia after the Fontan operation:Comparison of the intracardial lateral Tunnel, and the extracardiac conduits procedures.

27. Prof . dr. Gittenberger, LUMC, Leiden, FP7: Genes in heart valve development

29. Prof . dr. Willekens, Dr L. /Bonneux, NIDI / KNAW, Den Haag: Demography in CHD

30. Prof . dr. Bhattacharya, J.Goodship, Oxford, UK: Genetic architecture of Congenital heart disease

33. Drs. A.W. Schadenberg UMC Utrecht Neonatal thymectomy during heart surgery: consequences for the immune system in patients with TGA

34. Dr. Joziasse, UMC Utrecht. Genemutations in patients with TGA.

34.1. Joziasse IC, van de Smagt JJ, Smith K et al. Genes in congenital heart disease: atrioventricular valve formation. Basic Res Cardiol 2008 May

34.2. Joziasse IC, van der Smagt, JJ Poot M et al. A duplication including GATA4 does not co-segregate with congenital heart defects. Am J Med Genet 2009 May

34.3. Smith KA, Joziasse IC, Chocron S et al. Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 2009 June

34.4 Joziasse IC, Smith KA, Chocron S, van Dinther M, Guryev V, van de Smagt JJ, Cuppen E, Ten Dijke P, Mulder BJ, Maslen CL, Reshey B, Doevendans PA, Bakkers J.ALK2 mutation in a patient with Down's syndrome and a congenital heart defect. Eur J Hum Genet. 2011 Apr;19(4):389-93. Epub 2011 Jan.

Andere publicaties: 

Vis JC, Timmermans J, Post MC et al. Increased prevalence of migraine in Marfan syndrome. Int J Cardiol 2008 August 2

Van der Velde ET, Vriend JW, Mannens MM, Uiterwaal CS, Brand R, Mulder BJ. CONCOR, an initiative towards a national registry and DNA-bank of patients with congenital heart disease in the Netherlands: rationale, design, and first results.Eur J Epidemiol. 2005

Vriend JW, van der Velde ET, Mulder BJ. [National registry and DNA-bank of patients with congenital heart disease: the CONCOR-project]. Ned Tijdschr Geneeskd. 2004 Aug

Van der Velde ET, Vriend JWJ, Theeuwes E, Murk Jansen HDM, Kuiper J, Hoekstra WHGJ, Mulder BJM: Quality assurance measures in the CONCOR national registry and DNA-bank of patients with congenital heart disease in the Netherlands. Computers in Cardiology 30

Meijboom F, Mulder B. Problems in the organization of care for patients with adult congenital heart disease. Arch Cardiovasc Dis. 2010 Jun-July

K. van Engelen, J. Lam, J.H.M. Merks, M. Backes, M.J.H. Baars, H.J.H. van der Pal, A.V.Postma, R. Versteeg, H.N. Caron, B.J.M Mulder. Prevalence of congenital heart defects in neuroblastoma patients: a cohort study and systematic review of literature. Eur J Pediatr. 2008 Dec 17.

Vis, Jeroen C, van Engelen, Klaartje, Bouma, Berto J, Bilardo, Catia M, Blom, Nico A, Mulder, Barbara J. M. Cardiovascular disorders among persons with Down syndrome Book Series: International Review of Research in Mental Retardation, Volume: 39, Health issues among persons with Down syndrome. Pages: 165-194, Published: 2010

Vis JC, van Engelen K, Timmermans J, Hamel BC, Mulder BJ. Marfan syndrome masked by Down syndrome? Neth Heart J. 2009

Vis JC, Duffels MG, Winter MM et al. Down syndrome: a cardiovasculair perspectiveJ Intellect Disabil Res 2009 May

Vis JC, de Bruin-Bon RH, Bouma BJ, Backx AP, Huisman SA, Imschoot L, Mulder BJ. The sedentary heart: Physical inactivity is associated with cardiac atrophy in adults with an intellectual disability. Int. J. Cardiol, febr. 2011

Vis JC, van der Velde ET, Schuuring MJ, Engelfriet-Rijk LC, Harms IM, Mantels S, Bouma BJ, Mulder BJ. Wanted! 8000 heart patients: identification of adult patients with a congenital heart defect lost to follow-up. Int. J. Cardiol may 2011

Vis JC, de Bruin-Bon HA, Bouma BJ, Huisman SA, Imschoot L, van den Brink K, Mulder BJ. Adults with down syndrome have reduced cardiac response after light exercise testing. Net Heart J. febr 2012

Mulder BJ. Endocarditis in congenital heart disease: who is at highest risk? Circulation 2013 sept. 24

Schuuring MJ, Backx AP, Zwart R, Veelen-turf AH, Robbers-Visser D, Groenink M, Abu-Hanna A, Bruining N, Schijven MP, Mulder BJ, Bouma BJ. Mobile health in adults with congenital heart disease: cu-rrent use and future needs. Neth Heart J. 2016 Nov;24

 Bouma BJ, Mulder BJ.Changing Landscape of Congenital Heart Disease. Circ Res. 2017 Mar 17